Sökning: "endotoxic shock"

Hittade 5 avhandlingar innehållade orden endotoxic shock.

  1. 1. Pathophysiological, Inflammatory and Haemostatic Responses to Various Endotoxaemic Patterns : An Experimental Study in the Pig

    Författare :Miklós Lipcsey; Mats Eriksson; Jan Sjölin; Anders Larsson; Anders Bengtsson; Uppsala universitet; []
    Nyckelord :Anaesthesiology and intensive care; sepsis; animal model; cytokines; isoprostanes; endotoxic shock; pig; Anestesiologi och intensivvård;

    Sammanfattning : Septic shock is frequently seen in intensive care units and is associated with significant mortality. Endotoxin – a major mediator of the pathophysiologic responses – is released during lysis of Gram-negative bacteria. These responses can be mimicked in the endotoxaemic pig. LÄS MER

  3. 2. Nitric oxide in experimental sepsis

    Författare :Peter Dahm; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensive care; Nitric oxide; Sepsis; NO inhalation; Endotoxin; Acute lung injury; ARDS; Nitric oxide synthase; L-NMMA; L-NAME; Anestesiologi; Anaesthesiology; Pigs; intensivvård;

    Sammanfattning : Nitric oxide (NO) is important in the control of blood pressure and organ perfusion. In septic shock, NO produced by inducible NO-synthase (NOS) has been claimed to mediate pathological vasodilation and cell injury, while NO produced by constitutive NOS may be protective in counteracting hypoperfusion and organ injury. LÄS MER

  4. 3. Glucocorticoid receptors in severe inflammation : Experimental and clinical studies

    Författare :Maria Bergquist; Göran Hedenstierna; Christian Rylander; Catharina Lindholm; Cecile Martijn; Djillali Annane; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid receptor; sepsis; inflammation; flow cytometry; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Septic shock is one of the most common causes of mortality in intensive care, in spite of antibiotic treatment. Glucocorticoid treatment can be used to blunt an overwhelming immune response in severe inflammation. LÄS MER

  5. 4. Biomarkers in endotoxemia with a special interest in citrullinated histone H3

    Författare :Sofie Paues Göranson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Sepsis with multi-organ failure has an unacceptably high mortality rate of 25- 30% despite the use of antibiotics and modern intensive care. Attenuating the multi-organ failure and finding new biomarkers for early detection of septic shock would be of high clinical relevance in order to improve outcome. LÄS MER

  7. 5. Vascular Interactions in Innate Immunity and Immunothrombosis: : Models of Endothelial Protection

    Författare :Sofia Nordling; Peetra Magnusson; Paul Kubes; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endothelial cells; Thrombosis; Innate immunity; Immunothrombosis; Thromboinflammation; Immunologi; Immunology;

    Sammanfattning : The phenomenon known as immunothrombosis has garnered increased attention over the last few years. Much work has been done to characterize the cross talk between hemostasis and the innate immune system. LÄS MER