Sökning: "endothelin"

Visar resultat 21 - 25 av 116 avhandlingar innehållade ordet endothelin.

  1. 21. Endothelin and nitric oxide in the fetoplacental circulation

    Författare :Anna Sand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fetoplacental circulation; placental arteries; endothelin-1; nitric oxide; potassium channels; M-CSF; endothelin receptors; BKCa; ETA; ETB;

    Sammanfattning : Background: Normal fetal growth and development depend on a satisfactory uteroplacental and fetoplacental blood flow. This will ensure an adequate gaseous exchange and nutritional supply to the fetus. LÄS MER

  3. 22. Unusual vascular responses in the umbilical artery, mediated by endothelin-like receptors

    Författare :Maria Laursen; Urogynekologi och reproduktionsfarmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduction; sexuality; Obstetrik; gynekologi; andrologi; sexualitet; andrology; gynaecology; Obstetrics; Medicin människa och djur ; Medicine human and vertebrates ; unusual vascular responses; endothelin-like receptors; human umbilical artery; reproduktion;

    Sammanfattning : In this present study the population of endothelin-like receptors in the human umbilical artery was examined in vitro in different parts of the umbilical cord. Immunohistochemistry revealed ETB receptors in the endothelium and an uneven distribution of ETA receptors in the smooth muscle of the arterial wall, when comparing different parts of the umbilical artery. LÄS MER

  4. 23. The endothelin system and cardiopulmonary dysfunction in porcine endotoxin shock

    Författare :Michael Wanecek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; endothelin receptor antagonism; cyclooxygenase inhibition; endotoxin; sepsis; shock; pulmonary hypertension; cardiac dysfunction;

    Sammanfattning : The endothelium-derived peptide endothelin-1, acting via the endothelinA and endothelinB receptors, possesses strong vasoconstrictive properties shown to affect pulmonary and systemic circulation as well as cardiac function. During septic and endotoxin shock a marked increase in circulating plasma endothelin-1 levels is observed which is associated with morbidity, cardiac dysfunction and lung injury. LÄS MER

  5. 24. Endothelin and the regulation of peripheral and uteroplacental vascular tone during pregnancy

    Författare :Gunilla Ajne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; pregnancy; uteroplacental blood flow; peripheral resistance; endothelin receptors;

    Sammanfattning : The mechanism behind the vascular adaptation during pregnancy is poorly understood. The fall in peripheral resistance, particularly in the uterine vasculature, is crucial for sufficient increase in uteroplacental blood flow and thereby for normal fetal growth and development. LÄS MER

  7. 25. The role of hypoxia for the development of diabetic nephropathy : Temporal relationship and involvement of endothelin receptor signaling

    Författare :Stephanie Franzén; Fredrik Palm; Pamela K. Carmines; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephropathy; diabetes; hypoxia; EPR;

    Sammanfattning : Diabetic nephropathy is one of the most common causes of end stage renal disease and develops in approximately one third of all diabetes patients. Disease progression is characterized by deteriorating glomerular filtration rate and escalating urinary albumin/protein excretion; both are used as clinical markers for disease progression. LÄS MER