Sökning: "endothelin-1"

Visar resultat 21 - 25 av 68 avhandlingar innehållade ordet endothelin-1.

  1. 21. Endothelin and nitric oxide in the fetoplacental circulation

    Författare :Anna Sand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fetoplacental circulation; placental arteries; endothelin-1; nitric oxide; potassium channels; M-CSF; endothelin receptors; BKCa; ETA; ETB;

    Sammanfattning : Background: Normal fetal growth and development depend on a satisfactory uteroplacental and fetoplacental blood flow. This will ensure an adequate gaseous exchange and nutritional supply to the fetus. LÄS MER

  3. 22. The role of the endothelin system in experimental acute lung injury : with special reference to the formation of extra-vascular lung water

    Författare :Patrik Rossi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute lung injury; endothelin-1; extra-vascular lung water; pulmonary capillary pressure; sepsis; pulmonary edema; endotoxin;

    Sammanfattning : Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequent underlying cause of this pulmonary syndrome, which contains inflammation-induced diffuse alveolar damage and early stage high permeability edema. LÄS MER

  4. 23. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Författare :Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Sammanfattning : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. LÄS MER

  5. 24. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

  7. 25. Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study

    Författare :Astrid Ottosson-Seeberger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :endothelin-1; big ET-1; C-terminal big ET-1 22-3 8 fragment; hemodynamic; blood flow; fractional extraction; conversion; plasma half-life; end-stage renal failure; ischemic heart disease; hemodialysis; high-flux membrane; glucose uptake; insulin sensitivity;

    Sammanfattning : Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In this thesis, we studied the hemodynamic effects of big ET-1 in healthy humans focusing on the mechanisms of the effects (study I-IV). LÄS MER