Sökning: "endothelin receptors"

Visar resultat 16 - 20 av 41 avhandlingar innehållade orden endothelin receptors.

  1. 16. Endothelin and nitric oxide in the fetoplacental circulation

    Författare :Anna Sand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fetoplacental circulation; placental arteries; endothelin-1; nitric oxide; potassium channels; M-CSF; endothelin receptors; BKCa; ETA; ETB;

    Sammanfattning : Background: Normal fetal growth and development depend on a satisfactory uteroplacental and fetoplacental blood flow. This will ensure an adequate gaseous exchange and nutritional supply to the fetus. LÄS MER

  3. 17. Endothelin and the regulation of peripheral and uteroplacental vascular tone during pregnancy

    Författare :Gunilla Ajne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; pregnancy; uteroplacental blood flow; peripheral resistance; endothelin receptors;

    Sammanfattning : The mechanism behind the vascular adaptation during pregnancy is poorly understood. The fall in peripheral resistance, particularly in the uterine vasculature, is crucial for sufficient increase in uteroplacental blood flow and thereby for normal fetal growth and development. LÄS MER

  4. 18. The endothelin system and cardiopulmonary dysfunction in porcine endotoxin shock

    Författare :Michael Wanecek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; endothelin receptor antagonism; cyclooxygenase inhibition; endotoxin; sepsis; shock; pulmonary hypertension; cardiac dysfunction;

    Sammanfattning : The endothelium-derived peptide endothelin-1, acting via the endothelinA and endothelinB receptors, possesses strong vasoconstrictive properties shown to affect pulmonary and systemic circulation as well as cardiac function. During septic and endotoxin shock a marked increase in circulating plasma endothelin-1 levels is observed which is associated with morbidity, cardiac dysfunction and lung injury. LÄS MER

  5. 19. The role of hypoxia for the development of diabetic nephropathy : Temporal relationship and involvement of endothelin receptor signaling

    Författare :Stephanie Franzén; Fredrik Palm; Pamela K. Carmines; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephropathy; diabetes; hypoxia; EPR;

    Sammanfattning : Diabetic nephropathy is one of the most common causes of end stage renal disease and develops in approximately one third of all diabetes patients. Disease progression is characterized by deteriorating glomerular filtration rate and escalating urinary albumin/protein excretion; both are used as clinical markers for disease progression. LÄS MER

  7. 20. Vascular effects of endothelin in experimental lung injury

    Författare :Björn P Persson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acute lung injury;

    Sammanfattning : Acute lung injury remains a frequent and life threatening consequence of severe sepsis. This thesis has investigated the role of the endothelin (ET) system in sepsis-induced lung injury, with special reference to its effects on two hallmarks of this syndrome - formation of edema and pulmonary hypertension. LÄS MER