Sökning: "endothelin receptors"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden endothelin receptors.

  1. 1. Importance of MAPK and PKC in cerebrovascular endothelin receptor changes

    Författare :Marie Henriksson; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; toxikologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; Kardiovaskulära systemet; Cardiovascular system; Fysiologi; Physiology; cerebral arteries; ischemia; receptors; endothelin; Farmakologi;

    Sammanfattning : Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating vasodilatation. LÄS MER

  3. 2. Altered expression of contractile endothelin receptors in the vascular bed

    Författare :Mikael Adner; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; upregulation; transcriptional regulation; smooth muscle cells; plasticity; organ culture; Endothelin; receptor; Kardiovaskulära systemet;

    Sammanfattning : This thesis aims at characterizing the endothelin (ET) receptors in different vascular beds of man and rat. The ET-A receptor was shown to be the only contractile ET receptor present in all vascular regions, with the exception of the rat mesenteric vein where a weak ET-B receptor-mediated contraction was seen. LÄS MER

  4. 3. Endothelin and endothelin receptors in human pregnancy and delivery

    Författare :Kerstin Wolff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; endothelin receptor; human; pregnancy; preeclampsia; delivery;

    Sammanfattning : Background: Endothelin-1 (ET-1) is a 21-amino acid peptide, first described by Yanagisawa et al in 1988. It is one of the most potent constrictors of smooth muscle cells identified to date. LÄS MER

  5. 4. Endothelin and angiotensin II receptors in human coronary arteries and bypass grafts - Alterations in cardiovascular disease

    Författare :Angelica Wackenfors; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vasoconstriction; receptors; cardiovascular disease; human; coronary arteries;

    Sammanfattning : Angiotensin II (Ang II) and endothelin-1 (ET-1) induce strong vasoconstriction via activation of receptors on vascular smooth muscle cells. In this thesis, the contractile Ang II and endothelin receptors were examined in endothelium-denuded human coronary arteries and in bypass grafts (the left internal mammary artery and the saphenous vein), with focus on receptor alterations in cardiovascular disease. LÄS MER

  7. 5. Endothelin receptor changes during inflammation in the lung

    Författare :Bengt Granström; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Andningsorganen; Respiratory system; Upregulation; Smooth muscle cells; Smoking; Sephadex; Remodeling; Rat; mRNA; Human; ETB receptor; ETA receptor; Lung; Endothelin; Asthma bronchiale; Contraction;

    Sammanfattning : Endothelin-1 (ET-1) is an extremely potent smooth muscle spasmogen well known from the vascular system but also active within the airways. The importance of its proinflammatory and co-mitogenic properties has become increasingly evident, the endothelin system also having been shown to mimic the signal features of asthma, COPD and other pulmonary diseases. LÄS MER