Sökning: "endothelin receptor antagonists"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden endothelin receptor antagonists.

  1. 6. Cardiovascular effects of diesel exhaust : mechanistic and interventional studies

    Författare :Magnus Lundbäck; Anders Blomberg; Benoit Nemery; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; air pollution; diesel exhaust; nitrogen dioxide; endothelin-1; cardiovascular effects; exhaust particle trap; Lung diseases; Lungsjukdomar; lungmedicin; Lung Medicine;

    Sammanfattning : Background: Air pollution is associated with negative health effects. Exposure to combustion-derived particulate matter (PM) air pollution has been related to increased incidence of cardiovascular and respiratory morbidity and mortality, specifically in susceptible populations. Ambient particles, with a diameter of less than 2. LÄS MER

  3. 7. Splanchnic organ homeostasis in experimental endotoxin shock : with special reference to the endothelin and renin-angiotensin systems

    Författare :Anders Oldner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endotoxin; endothelin; angiotensin II shock; tonometry microdialysis; porcine; hypoxanthine; gut; splanchnic circulation; lactate; mucosal pHi;

    Sammanfattning : Splanchnic organ homeostasis may become severely deteriorated in states of sepsis and endotoxaemia. Gut tissue hypoxia with subsequent increases in intestinal mucosal permeability has been proposed to contribute to the development of multiple organ failure. LÄS MER

  4. 8. The role of the endothelin system in experimental acute lung injury : with special reference to the formation of extra-vascular lung water

    Författare :Patrik Rossi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute lung injury; endothelin-1; extra-vascular lung water; pulmonary capillary pressure; sepsis; pulmonary edema; endotoxin;

    Sammanfattning : Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequent underlying cause of this pulmonary syndrome, which contains inflammation-induced diffuse alveolar damage and early stage high permeability edema. LÄS MER

  5. 9. Endothelial function and dysfunction in coronary artery bypass grafting

    Författare :Ulf Lockowandt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CABG; Endothelin; Endothelin-blockers; endothelium; lactate; off-pump CABG; prostacyclin; radial artery; unstable angina pectoris;

    Sammanfattning : The integrity of the endothelium is of importance for short- and long-term results following coronary artery bypass grafting (CABG). In this thesis different factors of the endothelial role in the regulation of vascular tone in relation to various current aspects of CABG have been investigated. LÄS MER

  7. 10. Acute lung failure induced by tricyclic antidepressants : an experimental evaluation

    Författare :Karin Svens; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ARDS; tricyclic antidepressants; isolated lungs; rat; endothelin; endothelial cells; tight junctions;

    Sammanfattning : The tricyclic antidepressant drugs (TCA) have, over the years, been reported to be able to cause adult respiratory distress syndrome (ARDS)/acute lung injury in connection with overdose, and are currently among the most common cause of self-poisoning. Approximately 10% of all TCA overdose patients develop ARDS, and the treatment of these patients, irrespective of the event causing ARDS, is mainly supportive. LÄS MER