Sökning: "endothelial integrity"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden endothelial integrity.

  1. 1. Vessel wall integrity : influence of genetics and flow

    Författare :Hanna Björck; Toste Länne; Per Eriksson; Sverker Jern; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease (CVD) is the major cause of death worldwide. Underlying causes, such as atherosclerosis and hypertension, are associated with remodeling of the vessel wall ultimately leading to loss of structural integrity. There are a number of factors that can influence vascular remodeling and hence structural integrity. LÄS MER

  3. 2. Endothelial Nitric Oxide in the Control of Glomerular Hemodynamics

    Författare :János Pittner; Daniel H. Casellas; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Juxtamedullary nephron; afferent arteriole; nitric oxide; endothelial calcium; diaminofluoresceins; fura-2; autoregulation; shear stress; flow; videomicroscopy; Cellbiologi; Cell biology; Cellbiologi; Physiology; fysiologi;

    Sammanfattning : The afferent arteriole of the kidney is a unique vascular segment: it is the effector of the renal hemodynamic autoregulation. The use of the isolated, perfused juxtamedullary nephron preparation makes it possible to visualize the afferent arteriole while preserving its tissue surroundings and the functional integrity of the nephron. LÄS MER

  4. 3. Organ-specific mechanisms of vascular development in the mesentery

    Författare :Yang Zhang; Taija Mäkinen; Wiebke Herzog; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lymphatic vasculature; mesentery; hemogenic endothelium; lymphvasculogenesis; endothelial integrity; platelet; blood-filled lymphatic vessel; morphogenesis and maturation; compensation;

    Sammanfattning : Understanding how the vascular systems are formed has significant clinical importance. General mechanisms underlying vascular development have been extensively studied during the past decades. However, the mechanisms regulating the development and function of the blood and lymphatic vessels in specific organs are poorly understood. LÄS MER

  5. 4. Biological consequences of endothelial cell signaling

    Författare :Ross Smith; Lena Claesson-Welsh; Przemyslaw Sapieha; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; VEGFR2; Mechanosensing; Retinopathy; Biologi; Biology;

    Sammanfattning : Endothelial cells make up the inner lining of blood and lymphatic vessels, where they participate in functions vital to survival of the tissue; endothelial cells maintain vessel integrity, dynamically respond to the changing metabolic needs of tissues, and participate in many tissue-specific functions. Endothelial cells sense environmental cues which initiate signal transduction pathways that regulate behavior. LÄS MER

  7. 5. VEGFR-2 in Endothelial Differentiation and Vascular Organization

    Författare :Dan Edholm; Lena Claesson-Welsh; Xiujuan Li; Victoria Bautch; Uppsala universitet; []
    Nyckelord :Molecular medicine; Embryonic stem; VEGFR-2; Flk1; KDR; VEGF; vasculogenesis; angiogenesis; embryoid body; Molekylärmedicin;

    Sammanfattning : The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. LÄS MER