Sökning: "endothelial cell loss"
Visar resultat 21 - 25 av 75 avhandlingar innehållade orden endothelial cell loss.
21. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study
Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER
22. Organ-specific mechanisms of vascular development in the mesentery
Sammanfattning : Understanding how the vascular systems are formed has significant clinical importance. General mechanisms underlying vascular development have been extensively studied during the past decades. However, the mechanisms regulating the development and function of the blood and lymphatic vessels in specific organs are poorly understood. LÄS MER
23. Redox processes and oxidative stress in cell and tissue damage
Sammanfattning : Oxidative stress is described as an imbalance between oxidants and antioxidants, with a shift towards the oxidants. When the antioxidative systems are insufficient or the production of radicals is increased oxidative damage can occur, damaging DNA, lipids, and proteins. Oxidative stress has been implicated in several pathologies. LÄS MER
24. The role of the lymph node stroma in cancer and aging
Sammanfattning : The function of the lymph node (LN) stroma is crucial for the induction of an adaptive immune response. The stroma includes lymphatic vessels, high endothelial venules (HEVs) and mesenchymal cells (MCs). In this thesis, I have been investigating the role of the LN stroma in cancer and aging. LÄS MER
25. Making endothelial cells move : a study of angiomotin and binding partners
Sammanfattning : Angiogenesis is a process crucial for tumor growth and metastasis formation and encompasses the control of endothelial directional migration, anastomosis and lumen formation. We have previously shown that Angiomotin (Amot), a membrane-associated scaffold protein, plays an essential role in controlling endothelial cell migration and cellshape. LÄS MER