Sökning: "endothelial barrier dysfunction"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden endothelial barrier dysfunction.

1. 1. Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats

   Författare :Xiaoming Deng; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; Endothelial barrier permeability; Multiple organ dysfunction syndrome; Zymosan; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zymosan. LÄS MER

3. 2. Intestinal Ischemia and Reperfusion Injury - Pathophysiology as basis for novel treatment

   Författare :Zhengwu Sun; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ dysfunction; epithelium; endothelium; adhesion molecules; cytokines; protease inhibitor; Intestine; barrier; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Intestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction, as well as potential preventive and therapeutic modes of management were evaluated in the rat. LÄS MER

4. 3. Permeability of the glomerular filtration barrier in relation to the size, shape, charge and deformability of the permeating molecules

   Författare :Daniel Asgeirsson; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteinuria; capillary physiology; peritoneal membrane; dialysis; microalbuminuria; cardiovascular; endothelial dysfunction; diagnosis;

   Sammanfattning : Characterization of the glomerular filtration barrier is of fundamental importance for understanding the pathophysiology of proteinuric kidney diseases. Furthermore, it can be of key value in the understanding of microalbuminuria, which is often associated with endothelial dysfunction in conjunction with cardiovascular disease. LÄS MER

5. 4. Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies

   Författare :Joel Rasmuson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. Permeability changes of the vascular wall are important in functional immune responses and host defense. LÄS MER

7. 5. Properties of the endothelial cells and the glomerular barrier

   Författare :Jenny Sörensson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Capillary permeability; kidney glomerulus physiology; isolated perfused kidney; endothelium; orosomucoid; charge; horseradish peroxidase; inflammation; proteoglycan; cAMP.;

   Sammanfattning : The kidneys are vital organs that filter plasma to produce 180 liters of primary urine per day. Only 1% of this volume is excreted and the rest is reabsorbed. Naturally, such huge amounts of fluid must be well controlled to maintain the homeostasis, which is a prerequisite for life. LÄS MER