Sökning: "endoplasmic reticulum stress"

Visar resultat 16 - 20 av 53 avhandlingar innehållade orden endoplasmic reticulum stress.

  1. 16. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa

    Författare :Anna Franzén; Eva Brittebo; Ingvar Brandt; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; tissue-selective toxicity; bioactivation; olfactory mucosa; substituted dichlorobenzenes; Bowman s glands; sustentacular cells; ER stress; Grp78; caspase-12; caspase-3; CYP2A5; protein adduction; nasal toxicity; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. LÄS MER

  3. 17. Cytokines, alcohol metabolizing enzymes and stress-inducible ER proteins in alcoholic liver disease

    Författare :Che Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The release of inflammatory cytokines by Kupffer cells is believed to be a key step in the pathogenesis of alcoholic liver disease (ALD). Kupffer cells are activated not only by endotoxins [lipopolysaccharides (LPS)] but also by the lipid peroxidation products generated mainly via ethanol-inducible cytochrome P450 2E1 (CYP2E1) redox cycling. LÄS MER

  4. 18. Microsomal glutathione transferase 1 in anti-cancer drug resistance and protection against oxidative stress

    Författare :Katarina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the second leading cause of death in privileged countries. Tremendous efforts have been done to improve the efficiency of cancer treatment. Anti-cancer drug resistance is still a major problem in failure of cancer therapy. LÄS MER

  5. 19. Stress Response in Chronic Obstructive Pulmonary Disease - Effect of Cigarette Smoke Extract and Hypoxia on Structural Lung Cells

    Författare :Martin Garcia-Ryde; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; COPD; Cigarette smoke extract CSE ; Lung fibroblasts; Hypoxia; Gene expression;

    Sammanfattning : Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide according to the world health organization. It is a disease characterized by chronic inflammation and emphysema, and cigarette smoking is the main cause of COPD development. LÄS MER

  7. 20. Elucidation of pro-apoptotic signaling induced by cisplatin

    Författare :Aleksandra Mandic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Keywords: Cisplatin; apoptosis; signal transduction; Bak; calpain; endoplasmic reticulum;

    Sammanfattning : A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. LÄS MER