Sökning: "endoplasmic reticulum stress"
Visar resultat 11 - 15 av 53 avhandlingar innehållade orden endoplasmic reticulum stress.
11. The ubiquitin-proteasome system during proteotoxic stress
Sammanfattning : The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under patho-physiological conditions such as endoplasmic reticulum stress, which provoke the accumulation of aberrant proteins. LÄS MER
12. Insulin secretion and ASNA-1-dependent function of the endoplasmic reticulum in C. elegans
Sammanfattning : ASNA1 is a well-conserved ATPase involved in a wide range of functions, including cisplatin resistance, growth control, insulin secretion and targeting of tail-anchored (TA) proteins to membranes. It is a positive regulator of insulin secretion both in the roundworm Caenorhabditis elegans and in humans. LÄS MER
13. Palmitate-induced Apoptosis in Insulin-producing β-cells
Sammanfattning : Type 2 diabetes is a disease characterized by the inability of pancreatic β-cells to secrete sufficient amounts of insulin to maintain normoglycemia. Increased levels of saturated fatty acids such as palmitate are believed to contribute to β-cell failure and the development of the disease. LÄS MER
14. Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
Sammanfattning : Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. The association of IRE1 dysregulation with a wide range of human diseases, stimulated research towards the discovery of small organic molecules able to modulate IRE1 signalling, and to potentially be used as novel therapeutics. LÄS MER
15. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice
Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. LÄS MER