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Visar resultat 1 - 5 av 53 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

    Författare :Krzysztof Kucharz; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fragmentation; fission; endoplasmic reticulum; neurons; FRAP; primary cultures; organotypic slice cultures; in vivo; in situ; calcium; fusion; NMDA receptor; 2-photon microscopy; confocal microscopy;

    Sammanfattning : The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. LÄS MER

  3. 2. Engineering the Secretory Pathway for Recombinant Protein Secretion in Saccharomyces cerevisiae

    Författare :Jichen Bao; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; endoplasmic reticulum; oxidative stress; GLO3; protein secretion; transcriptomics; drug screening; Saccharomyces cerevisiae; SEC16;

    Sammanfattning : In the past few decades there has been an increasing demand of biopharmaceutical proteins in the market. Several types of cell factories are applied to produce different pharmaceutical proteins. LÄS MER

  4. 3. Characterisation of the novel endoplasmic reticulum chaperone ERDJ5

    Författare :Paula Cunnea; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endoplasmic reticulum; chaperone; unfolded protein response; protein folding; disease;

    Sammanfattning : Communication between cells depends to a large extent on interactions between secreted proteins and membrane receptors. Therefore their production and release must be strictly regulated. Proteins that are destined for the extracellular space assemble and fold in the endoplasmic reticulum (ER). LÄS MER

  5. 4. Protein expression analysis of insulin producing cells exposed to endoplasmic reticulum stress

    Författare :Victoria Rosengren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly as a result of the obesity epidemic. T2DM develops in individuals who fails to compensate for increased demand of insulin. LÄS MER

  7. 5. Plant Calreticulins - isoforms, localization and function

    Författare :Karin Svensson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; arabidopsis thaliana; calcium; isoform; endoplasmic reticulum; chaperone; tunicamycin;

    Sammanfattning : Calreticulin (CRT) is an endoplasmic reticulum (ER)-located protein involved in quality control of newly synthesized proteins as well as in calcium homeostasis of the cell. Most of what is known about CRT arises from studies of mammalian systems. LÄS MER