Sökning: "endopeptidase"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet endopeptidase.

1. 1. Substance P Endopeptidase : Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition

   Författare :Krister Karlsson; Lars Oreland; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Substance P Endopeptidase; Neuropeptide; Central Nervous System; Purification; Drug Dependence; Heat Stress; Farmakologi; Pharmacological research; Farmakologisk forskning;

   Sammanfattning : The purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. LÄS MER

3. 2. Interpreting a Giant : Studies of Structure and Function of Tripeptidyl-peptidase II

   Författare :Sandra Eklund; Birgitta Tomkinson; Beate Rockel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tripeptidyl-peptidas II; molecular ruler; sequence signatures; pH-dependence; endopeptidase; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : Tripeptidyl-peptidase II (TPP II) is a subtilisin-like serine peptidase that forms a gigantic homooligomeric complex, and is involved in the degradation of peptides in the cytosol. In addition, TPP II has been implicated in specific cellular processes, such as apoptosis control and adipogenesis, but if this is dependent on its endo- or exopeptidase activity remains to be determined. LÄS MER

4. 3. Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain

   Författare :Mathias Hallberg; Fred Nyberg; Pierre Le Grevès; James Zadina; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; NK1 receptor; Substance P 1-7 ; Endopeptidase; Opioids; Calcitonin gene-related peptide; Radioimmunoassay; Autoradiography; Central nervous system; Rats; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

   Sammanfattning : Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. LÄS MER

5. 4. Studies of interactions with Streptococcus equi and the host : extracellular proteins of Streptococcus equi subspec. equi and Streptococcus equi subspec. zooepidemicus

   Författare :Greta Hulting; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Streptococcus equi subspecies equi (S. equi) causes strangles, a highly contagious and serious disease in the upper respiratory tract of horses, with a worldwide distribution. Streptococcus equi subspecies zooepidemicus (S. LÄS MER

7. 5. The streptococcal IgG degrading enzyme IdeS : studies on host-pathogen interactions

   Författare :Jenny Johansson Söderberg; Ulrich von Pawel-Rammingen; Jan Ingemar Flock; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; streptococcus pyogenes; IdeS; molekylärbiologi; Molecular Biology;

   Sammanfattning : The important human pathogen Streptococcus pyogenes causes both mild infections such as pharyngitis and impetigo but also severe life threatening invasive infections.  Specific antibodies (IgG) recognize pathogens and are important mediators for pathogen clearance by the immune defence. S. LÄS MER