Sökning: "endogenous opioid system"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden endogenous opioid system.

1. 1. Molecular Adaptations in the Endogenous Opioid System in Human and Rodent Brain

   Författare :Muhammad Zubair Hussain; Georgy Bakalkin; Anita Hansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endogenous Opioid System; Dynorphins; Lateralization; Alcohol Dependence; Emotions; Traumatic Brain Injury; Anterior Cingulate Cortex; Dorsal Striatum; Neuroscience; Neurovetenskap;

   Sammanfattning : The aims of the thesis were to examine i) whether the endogenous opioid system (EOS) is lateralized in human brain areas involved in processing of emotions and pain; ii) whether EOS responses to unilateral brain injury depend on side of lesion, and iii) whether in human alcoholics, this system is involved in molecular adaptations in brain areas relevant for cognitive control of addictive behavior and habit formation.The main findings were that (1) opioid peptides but not opioid receptors and classic neurotransmitters are markedly lateralized in the anterior cingulate cortex involved in processing of  positive and negative emotions and affective component of pain. LÄS MER

3. 2. The hippocampal opioid system : role in spatial learning

   Författare :Johan Sandin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :opioid; dynorphin; nociceptin; hippocampus; learning; memory; acetylcholine; HPLC; microinjections;

   Sammanfattning : The main aim of the present thesis was to study the role of the endogenous hippocampal opioid system, and in particular, the role of dynorphin B and nociceptin, in spatial learning. The effects of bilateral infusion (using chronic cannulae) of dynorphin B into the dorsal hippocampus (CA3-region), an area containing a high number of dynorphin-containing neurons, were examined in the Morris swim-maze, a spatial task dependent on hippocampal functioning. LÄS MER

4. 3. Opioid and non-opioid activities of the dynorphins

   Författare :Zoya Marinova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN). Dynorphins regulate pain processing and memory acquisition and modulate reward induced by intake of addictive substances. LÄS MER

5. 4. Imaging of the brain opioid system in amphetamine dependence

   Författare :Joar Guterstam; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Amphetamine dependence is a global health problem, often giving rise to severe medical and social complications in affected individuals. Unfortunately, there is still limited evidence for any specific treatment that would help amphetamine dependent patients to avoid relapse. LÄS MER

7. 5. Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides

   Författare :Rebecka Klintenberg; Alan Crossman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Opioid peptides; dyskinesia; Parkinson s disease; mass spectrometry; metabolism; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning; biologisk beroendeforskning; Biological Research on Drug Dependence;

   Sammanfattning : Dyskinesias or abnormal involuntary movements are a debilitating complication of long-term levodopa treatment of Parkinson’s disease (PD) that is widely experienced and may compromise the efficacy of the drug therapy. Tardive dyskinesia is another important adverse effect seen with antipsychotic drug treatment. LÄS MER