Sökning: "endogenous opioid peptides"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden endogenous opioid peptides.

1. 1. Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides

   Författare :Rebecka Klintenberg; Alan Crossman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Opioid peptides; dyskinesia; Parkinson s disease; mass spectrometry; metabolism; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning; biologisk beroendeforskning; Biological Research on Drug Dependence;

   Sammanfattning : Dyskinesias or abnormal involuntary movements are a debilitating complication of long-term levodopa treatment of Parkinson’s disease (PD) that is widely experienced and may compromise the efficacy of the drug therapy. Tardive dyskinesia is another important adverse effect seen with antipsychotic drug treatment. LÄS MER

3. 2. Molecular Adaptations in the Endogenous Opioid System in Human and Rodent Brain

   Författare :Muhammad Zubair Hussain; Georgy Bakalkin; Anita Hansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endogenous Opioid System; Dynorphins; Lateralization; Alcohol Dependence; Emotions; Traumatic Brain Injury; Anterior Cingulate Cortex; Dorsal Striatum; Neuroscience; Neurovetenskap;

   Sammanfattning : The aims of the thesis were to examine i) whether the endogenous opioid system (EOS) is lateralized in human brain areas involved in processing of emotions and pain; ii) whether EOS responses to unilateral brain injury depend on side of lesion, and iii) whether in human alcoholics, this system is involved in molecular adaptations in brain areas relevant for cognitive control of addictive behavior and habit formation.The main findings were that (1) opioid peptides but not opioid receptors and classic neurotransmitters are markedly lateralized in the anterior cingulate cortex involved in processing of  positive and negative emotions and affective component of pain. LÄS MER

4. 3. Opioid and non-opioid activities of the dynorphins

   Författare :Zoya Marinova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN). Dynorphins regulate pain processing and memory acquisition and modulate reward induced by intake of addictive substances. LÄS MER

5. 4. Methods and detection of endogenous peptides in the CNS and GI tract

   Författare :Anja Finn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :antibody; characterization; radioimmunoassay; opioid peptides; orexins;

   Sammanfattning : Endogenous peptides, such as enkephalins, endorphins and orexins modulate a variety of biological processes; these peptides are found in the central nervous system and periphery, including the gastrointestinal tract. One of the methods commonly used to determine localization, concentration, expression and function of endogenous peptides is the radio immunoassay (RIA). LÄS MER

7. 5. Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model

   Författare :Pia Steensland; Christina Gianoulakis; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Anabolic Androgenic Steroids AAS ; aggression; alcohol intake; defensive behaviours; dependence; opioid peptides; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

   Sammanfattning : A new group of anabolic androgenic steroid (AAS) users has developed during the last two decades. This group consists primarily of young men interested in improving their physical appearance. Within this group, AAS are sometimes used together with other illicit drugs, alcohol and nicotine. LÄS MER