Sökning: "endocytosis"

Visar resultat 6 - 10 av 128 avhandlingar innehållade ordet endocytosis.

  1. 6. Reciprocal regulation of endocytosis and signaling in Drosophila epithelial development and aberrant growth

    Författare :Dan Liu; Christos Samakovlis; Vasilios Tsarouhas; Héctor Herranz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; endocytosis; protein sorting; RTK signaling; airway maturation; tumor-suppressive cell competition; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Endocytosis and subsequent endosomal sorting of plasma membrane proteins and nutrients are essential for cellular homeostasis. Previous work has uncovered several different internalization mechanisms, endosomal sorting routes and aspects of their regulation. LÄS MER

  3. 7. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function

    Författare :Anders Wittrup; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; heparan sulfate; glypican; endocytosis; drug delivery; DNA uptake; Cancer; cell penetrating peptides; non-viral gene delivery; organelle purification; proteoglycan; syndecan.;

    Sammanfattning : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. LÄS MER

  4. 8. Regulation of epithelial morphogenesis in Drosophila by the Emp scavenger receptor

    Författare :Ana Sofia Pinheiro; Christos Samakovlis; Sofia Araújo; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Emp; scavenger receptor; CD36; cytoskeleton; Src kinase; Diap; DrICE; Hipo Yki; endocytosis; Drosophila; airways; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The respiratory system of Drosophila melanogaster, the trachea, is widely used as a model system to study the development of branched tubular organs. Airway maturation in Drosophila entails a series of sequential events: first, a massive apical secretion of luminal proteins initiates diametric tube expansion, second an endocytic wave removes luminal proteins and finally liquid clearance and gas filling converts the nascent epithelial tubes to a functional respiratory organ. LÄS MER

  5. 9. Pathogen entry mechanisms and endocytic responses to plasma membrane damage

    Författare :Lars Nygård Skalman; Richard Lundmark; Kristian Riesbeck; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocytosis; plasma membrane; pathogens; virus; bacterial membrane vesicles; Helicobacter pylori; adenovirus 37; listeriolysin O; pore-forming toxins; membrane repair;

    Sammanfattning : Endocytosis is a fundamental cellular process by which cells transport material from the outside to the inside of the cell through the formation of membrane invaginations that bud off from the plasma membrane. This process is important for nutrient uptake, regulating cell surface receptors and the overall plasma membrane composition. LÄS MER

  7. 10. Mucins, Cystic Fibrosis and PDZ protein interactions

    Författare :Emily Malmberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

    Sammanfattning : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. LÄS MER