Sökning: "endocrine-disrupting activity"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden endocrine-disrupting activity.

1. 6. Interaction of Xenobiotics with the Glucocorticoid Hormone System in vitro

   Författare :Maria Johansson; Helen Håkansson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; DDT; PCB; tolylfluanid; adrenal; CYP11B1; glucocorticoid receptor; endocrine disrupter; Biologi; Biology; Biologi; Ecotoxicology; ekotoxikologi;

   Sammanfattning : Persistent environmental pollutants were examined for their interaction with the glucocorticoid hormone system. The focus was placed on interference with the glucocorticoid synthesis and the glucocorticoid-signalling pathway in various in vitro test systems. LÄS MER

3. 7. Steroidogenesis studied in a human adrenocortical cell line : effects of single chemicals and mixtures

   Författare :Åsa Ohlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Steroidogenesis may be a target for endocrine disrupting chemicals; unfortunately data of such effects is limited. The aim of this thesis was to study effects on steroidogenesis of single chemicals and mixtures in the human adrenocarcinoma cell line H295R. Screening for effects on steroid secretion was performed by ELISA. LÄS MER

4. 8. Interaction of brominated flame retardants with the chicken and zebrafish androgen receptors

   Författare :Solomon Asnake; Per-Erik Olsson; Dennis Larsson; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DBE-DBCH; TBP-AE; TBP-BAE; TBP-DBPE; gene transcription; Biology; Biologi;

   Sammanfattning : The survival of organisms depends on their ability to use different signaling pathways to adapt to the environment. The endocrine system consists of glands that release hormones to the blood stream. Male reproductive functions are regulated by androgens through interactions with the androgen receptor (AR). LÄS MER

5. 9. The juvenile three-spined stickleback : model organism for the study of estrogenic and androgenic endocrine disruption in laboratory and field

   Författare :Edda Hahlbeck; Bengt-Erik Bengtsson; Poul Bjerregaard; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; endocrine disruption; Terrestrial; freshwater and marine ecology; Terrestisk; limnisk och marin ekologi;

   Sammanfattning : Industrial and domestic sewage effluents have been found to cause reproductive disorders in wild fish, often as a result of the interference of compounds in the effluents with the endocrine system. This thesis describes laboratory-based exposure experiments and a field survey that were conducted with juveniles of the three-spined stickleback, Gasterosteus aculeatus. LÄS MER

7. 10. Interactions between cytochrome P450 and estrogenic compounds in fish

   Författare :Linda Hasselberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; CYP1A; CYP3A; glutathione; alkylphenols; ethynylestradiol; ketoconazole; vitellogenin; Atlantic cod; rainbow trout; fish;

   Sammanfattning : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. LÄS MER