Sökning: "endocrine-disrupting activity"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden endocrine-disrupting activity.
Sammanfattning : Endocrine-disrupting compounds (EDCs) such as hormones and certain pharmaceuticals (i.e. birth control pills, oestrogen replacement products and other steroids) can interfere with the regulatory systems of humans and wildlife. Many of these compounds are excreted by humans and released with sewage. LÄS MER
Sammanfattning : Evidence from an abundant number of studies suggests that human female reproductive functions have become impaired over the past half century and that there might be a relationship between endocrine disrupting chemicals (EDCs) and reduced fertility. It is, however, not known by what mechanisms EDCs affect different reproductive functions such as endometrial receptivity, embryo implantation and placentation. LÄS MER
Sammanfattning : Currently, over 100 high-volume chemicals have been classified as endocrine disrupters. One of these is nonylphenol, which was used as the model compound in this study. This substance originates mainly from the degradation of non-ionic surfactants (nonylphenol ethoxylates) which are widely used in industrial and domestic applications. LÄS MER
Sammanfattning : Persistent environmental pollutants were examined for their interaction with the glucocorticoid hormone system. The focus was placed on interference with the glucocorticoid synthesis and the glucocorticoid-signalling pathway in various in vitro test systems. LÄS MER
5. Steroidogenesis studied in a human adrenocortical cell line : effects of single chemicals and mixtures
Sammanfattning : Steroidogenesis may be a target for endocrine disrupting chemicals; unfortunately data of such effects is limited. The aim of this thesis was to study effects on steroidogenesis of single chemicals and mixtures in the human adrenocarcinoma cell line H295R. Screening for effects on steroid secretion was performed by ELISA. LÄS MER