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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Upper gastrointestinal dysmotility - from endocrinological pathogenesis to symptoms

    Författare :Julia Borg; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxytocin; gastroparesis; functional dyspepsia; upper gastrointestinal dysmotility; CCK; gastrin; vasopressin; esophageal dysmotility; satiety; diabetes mellitus; endocrine dysregulation; gastric emptying; gastric emptying scintigraphy; gastric emptying manometry; autonomic neuropathy;

    Sammanfattning : Gastrointestinal dysmotility is common, particularly in patients with diabetes mellitus. The aim of this thesis is to explore whether gastrointestinal dysmotility and endocrine secretion are interrelated, and how the symptoms manifest themselves in these patients. LÄS MER

  3. 2. The endocrine system in the progression of mild cognitive impairment to dementia

    Författare :Patrick Quinlan; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thyroid hormones; Insulin-like growth factor-I; Alzheimer’s disease; Vascular dementia; Mild cognitive impairment;

    Sammanfattning : Background and aims: Endocrine alterations have been related to cognitive decline, but the role of hormones may vary along the progression to manifest dementia. The overall aim of this thesis was to assess whether thyroid hormones (THs) and insulin-like growth factor-I (IGF-I) are dysregulated around the onset of Alzheimer’s disease (AD) and vascular dementia (VaD). LÄS MER

  4. 3. Molecular mechanisms of AhR mediated endocrine disruption of estrogen and retinoic acid signalling pathways

    Författare :David Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered to be one of the most toxic compounds known to man. LÄS MER

  5. 4. Long-term Effects of Opioids in the Treatment of Chronic Pain : Investigation of Problems and Hazards on Clinical, Biochemical, Cellular and Genetic Levels

    Författare :Annica Rhodin; Torsten Gordh; Fred Nyberg; Mats Stridsberg; Mats Enlund; Harald Breivik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; opioid; chonic pain; long-term opioid treatment; Anaesthetics; Anestesiologi; Anestesiologi; Anaesthesiology;

    Sammanfattning : After two decades of liberal prescribing of opioids, there has been an increasing recognition of problems connected to the prolonged use of opioids for chronic pain. The aim of my thesis was to explore some consequences of long-term opioid treatment for chronic pain such as problematic opioid use, endocrine disorders, tolerance and genetic variations in pain and opioid response. LÄS MER

  7. 5. Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System

    Författare :Ulrikke Voss; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enteric nervous system; high fat diet; neuropathy; neuroplasticity; metabolic imbalance;

    Sammanfattning : Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. LÄS MER