Sökning: "endocrine dysregulation"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden endocrine dysregulation.
Sammanfattning : Gastrointestinal dysmotility is common, particularly in patients with diabetes mellitus. The aim of this thesis is to explore whether gastrointestinal dysmotility and endocrine secretion are interrelated, and how the symptoms manifest themselves in these patients. LÄS MER
Sammanfattning : Background and aims: Endocrine alterations have been related to cognitive decline, but the role of hormones may vary along the progression to manifest dementia. The overall aim of this thesis was to assess whether thyroid hormones (THs) and insulin-like growth factor-I (IGF-I) are dysregulated around the onset of Alzheimer’s disease (AD) and vascular dementia (VaD). LÄS MER
3. Molecular mechanisms of AhR mediated endocrine disruption of estrogen and retinoic acid signalling pathways
Sammanfattning : Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered to be one of the most toxic compounds known to man. LÄS MER
4. Long-term Effects of Opioids in the Treatment of Chronic Pain : Investigation of Problems and Hazards on Clinical, Biochemical, Cellular and Genetic Levels
Sammanfattning : After two decades of liberal prescribing of opioids, there has been an increasing recognition of problems connected to the prolonged use of opioids for chronic pain. The aim of my thesis was to explore some consequences of long-term opioid treatment for chronic pain such as problematic opioid use, endocrine disorders, tolerance and genetic variations in pain and opioid response. LÄS MER
Sammanfattning : Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. LÄS MER