Sökning: "endocrine disruptors"
Visar resultat 6 - 10 av 17 avhandlingar innehållade orden endocrine disruptors.
6. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)
Sammanfattning : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. LÄS MER
7. Fish on drugs : behaviour modifying contaminants in aquatic ecosystems
Sammanfattning : Contamination of surface waters is a worldwide problem. One group of emerging contaminants that reach aquatic ecosystems via sewage treatment plant effluents and agricultural run-offs is pharmaceuticals. LÄS MER
8. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis
Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER
9. Zebrafish as a model to study the neuroendocrine system and toxicity of endocrine disruptors
Sammanfattning : Zebrafish is a popular vertebrate model system to study development and perform genetic analysis. It offers numerous advantages such as small size, short generation time, high fecundity, rapid and ex utero development of embryos and optically transparent embryos. LÄS MER
10. Effects of mixtures of endocrine disrupting chemicals – Thyroid disruption and behavioural effects in fish models
Sammanfattning : Wildlife and humans are continuously exposed to thousands of man-made compounds, including chemicals that are able to act as endocrine disruptors (EDCs). These pollutants are able to affect vital processes including brain development, reproduction, metabolism and growth. LÄS MER