Sökning: "endochondral bone formation"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden endochondral bone formation.

1. 1. Molecular regulators in cartilage and bone formation

   Författare :Thomas Engstrand; Uppsala universitet; []
   Nyckelord :Medical sciences; cartilage; bone; TGF-beta; BMP; noggin; gene therapy; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Cartilage functions as a scaffold for bone formation during development. This process, endochondral ossification, is regulated by systemic hormones and local growth factors. LÄS MER

3. 2. Matrix resorption in endochondral bone growth : ultrastructural studies, with special attention to the chondroclast

   Författare :Joakim Nordahl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :chondroclast; osteoclast; cartilage resorption; TRAP; cathepsin K; fibronectin; bone sialoprotein; osteopontin;

   Sammanfattning : A substantial amount of the calcified cartilage in the distal parts of the epiphyseal plate is resorbed during endochondral growth of long bones. However, the mechanisms involved in this process are still largely unknown. On the other hand, bone-resorption in the lower metaphysis has been thoroughly investigated. LÄS MER

4. 3. Insulin-like growth factor-I from a perspective of bone regeneration

   Författare :Per Prisell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :insulin-like growth factor-I; fracture healing; endochondral bone formation; slow release; indomethacin; corticosteroids; hyaluronan; von Kossa;

   Sammanfattning : The insulin-like growth factor I (IGF-I) is produced by osteoblasts and many other cell types. IGF-I is abundant in bone matrix and mediates some of the effects of growth hormone (GH). The present investigations have focused on IGF-I actions during bone regeneration. LÄS MER

5. 4. Thyroid hormone receptors and the regulation of bone physiology

   Författare :Jenny Kindblom; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : The aim of the studies in this thesis was to investigate the role of thyroid hormone receptors in bone physiology. Thyroid hormone signals through its receptors, the TRs, and has profound effects on bone development and metabolism, as demonstrated in hypo- and hyperthyroidism. LÄS MER

7. 5. Articular and epiphyseal cartilage : its formation, maintenance and repair

   Författare :Lei Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Long bones develop via a series of ordered processes, initiated from mesenchymal stem cell condensation, cartilage anlagen formation, followed by central cell hypertrophy and vascular invasion and the finalized by the formation of primary and secondary ossification centers (SOC), where the latter is also called endochondral ossification. As long bone develops, it can be distinguished in to several morphologically distinct parts: the main shaft of a long bone, called diaphysis; a narrow disc of growth plate, providing a continuous supply of chondrocytes for longitudinal growth; a thin layer of articular cartilage at the ends of epiphysis, supporting joint movement, and a SOC, sandwiched between the two pieces of cartilage. LÄS MER