Sökning: "enabling formulation"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden enabling formulation.

  1. 1. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System

    Författare :Caroline Alvebratt; Christel Anna Sofia Bergström; Maria Strömme; Caitriona O'Driscoll; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amorphous solid dispersion; coadministration; digestion; dissolution; drug absorption; enabling formulation; in vitro assay; lipid-based formulation; mesoporous carrier; supersaturation; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. LÄS MER

  3. 2. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

    Författare :Linda C. Alskär; Christel Bergström; Brendan Griffin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. LÄS MER

  4. 3. On problems, joint problem solving and change - A human behavioural approach in a construction sector context

    Författare :Lars Sunding; Byggproduktion; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Problem solving.; Human behavior and psychology; Information distortion; Problem formulation; Action research; Behavioral Change; Collaboration; Construction sector;

    Sammanfattning : Critics maintain that there are a number of troublesome issues resulting from the construction sector’s way of operating and that these remain, despite widespread criticism and measures designed to change all of this. The construction sector’s and the critics’ manner of describing these problems fails to a large extent to take into consideration the way people function in connection with practical problem solving. LÄS MER

  5. 4. Numerical simulation of thermomechanical rolling contact using an arbitrary Lagrangian-Eulerian formulation

    Författare :Andreas Draganis; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; rolling contact; finite element method; thermomechanical analysis; arbitrary Lagrangian--Eulerian;

    Sammanfattning : In the endeavour to further the understanding of thermomechanical rolling contact, numerical simulations serve as an important complement to laboratory and full-scale testing. In the development of numerical simulation methods, the challenge is to enhance predictive capabilities while keeping computational efforts reasonable. LÄS MER

  7. 5. One Image, Many Insights: A Synergistic Approach Towards Enabling Autonomous Visual Inspection

    Författare :Vignesh Kottayam Viswanathan; George Nikolakopoulos; Dimitrios Kanoulas; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Unified autonomy; aerial robotics; space robotics; Robotics and Artificial Intelligence; Robotik och artificiell intelligens;

    Sammanfattning : Visual inspection in autonomous robotics is a task in which autonomous agents are required to gather visual information of objects of interest, in a manner that ensures safety, efficiency and comprehensive coverage. It is, therefore, crucial for identifying key landmarks, detecting cracks or defects, or reconstructing the observed object for detailed analysis. LÄS MER