Sökning: "embryonic inner ear"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden embryonic inner ear.

1. 1. Applications of organ culture of the mouse inner ear

   Författare :Diana Berggren; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ culture; embryonic inner ear; intercellular junctions; aminoglycosides; statoacoustic ganglion; intermediate filaments; collagen; endolymph;

   Sammanfattning : The embryonic mouse inner ear was used as a model with which to study ototoxicity and tissue interactions. The inner ear anlage can be explanted and cultured in vitro from about the 12th gestational day (gd), and will differentiate parallel with the inner ear developing in vivo until a time corresponding to birth (21st gd). LÄS MER

3. 2. Investigating a cell replacement therapy in the inner ear

   Författare :Zhengqing Hu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adult neural stem cell; Cell therapy; Differentiation; Dorsal root ganglion; Embryonic stem cell; Gene transfer; Hearing loss; Nerve growth factor; Neurogenin; Organ of Corti; Spiral ganglion; Transplantation;

   Sammanfattning : The mammalian auditory system is sensitive to genetic disorders, aging and injuries caused by overstimulation, ototoxic drugs and viral infections. Since the sensory epithelium (the organ of Corti) and the spiral ganglion neurons (SGNs) in adult mammalian do not regenerate spontaneously when they are damaged, a cell substitution strategy was proposed to compensate the function of the degenerated SGNs. LÄS MER

4. 3. The importance of Foxi1 expression in kidney and inner ear

   Författare :Sandra Rodrigo Blomqvist; Göteborgs universitet; []
   Nyckelord :Foxi1; intercalated cells; endolymphatic sac; acid base regulation;

   Sammanfattning : The forkhead (FOX) genes comprise a family of transcription factors involved in generegulation in both embryonic and adult tissue. Foxi1 is expressed in the kidney andthe developing inner ear. We examined the significance of Foxi1 in these two organsand explain the molecular mechanisms behind the phenotype seen in Foxi1 deficientmice. LÄS MER

5. 4. Characterization of cochlear degeneration in the inner ear of the German waltzing guinea pig : a morphological, cellular, and molecular study

   Författare :Zhe Jin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cochlea; Deafness; Embryonic development; Inner ear; Melanocyte; Phenotype; Recessive genes; Recycling; Stria vascularis.;

   Sammanfattning : The German waltzing guinea pig is a new strain of animals with yet unknown gene mutation(s) displaying recessively inherited cochleovestibular impairment. The homozygous animals (gw/gw) are deaf already at birth and display Wpical waltzing behavior throughout life. LÄS MER

7. 5. Stem cell in-vitro strategies for the induction of sensory neurons for inner ear cell therapy

   Författare :Rouknuddin Qasim Ali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The cochlea, a part of the auditory system, is a complex structure consisting of several different types of cells including hair cells and spiral ganglion neurons. In mammals, the regenerative potential of hair cells and spiral ganglion neurons is lost soon after the birth and damage to any of these cells causes sensorineural hearing loss. LÄS MER