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1. 1. Intracellular pathways involved in formation and degradation of prions

   Författare :Elin Allard; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Prions cause invariably fatal neurodegenerative diseases, in which a misfolded host-encoded protein appears to be the main, if not the only, component of the infectious agent. During disease, a normal cellular protein, PrPC, is converted to a disease-related isoform, PrPSc, by a post-translational process that might require auxiliary cellular cofactors. LÄS MER