Sökning: "elastin degradation"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden elastin degradation.

  1. 1. Computational model of abdominal aortic aneurysm inception and evolution

    Författare :Andrii Grytsan; T. Christian Gasser; Nicholas Hill; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; aneurysm; three dimensional; elastin degradation; growth; remodeling; fluid-solid-growth model; Teknisk mekanik; Engineering Mechanics;

    Sammanfattning : Incidence of abdominal aortic aneurysm (AAA) is increasing in the aging society of the western world. Development of AAA is mostly asymptomatic and is characterized by a bulge in the abdominal aorta. However, AAA may suddenly rupture, which results in an internal bleeding associated with a high mortality rate. LÄS MER

  3. 2. Innate immunity in atherosclerosis : the role of pattern recognition receptors

    Författare :Xiao-Ying Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pathogenesis of atherosclerosis is greatly influenced by the activities of both innate and adaptive immunity. Danger signals such as cholesterol crystals, oxidized LDL, and modified phospholipids may trigger sterile inflammation in atherosclerosis. LÄS MER

  4. 3. Significance of intraluminal thrombus in abdominal aortic aneurysm

    Författare :Maggie Folkesson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most AAAs contain an intraluminal thrombus (ILT) and the volume of the ILT correlates with aneurysm size. The thrombus-covered wall is a common site for rupture after bleeding into the ILT. The hypothesis for this thesis was generated when Kazi et al discovered differences in AAA wall between ILT covered and ILT free aortic wall. LÄS MER

  5. 4. Biomechanics of abdominal aortic aneurysm:Experimental evidence and multiscale constitutive modeling

    Författare :Giampaolo Martufi; T. Christian Gasser; Tim McGloughlinm; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : The reliable assessment of Abdominal Aortic Aneurysm (AAA) rupture risk is critically important in reducing related mortality without unnecessarily increasing the rate of elective repair. A multi-disciplinary approach including vascular biomechanics and constitutive modeling is needed to better understand and more effectively treat these diseases. LÄS MER

  7. 5. Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture

    Författare :Monsur Kazi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AAA; thrombus; proteases; NGAL; mast cells;

    Sammanfattning : Fragmentation of elastin, loss of smooth muscle cells (SMCs) and accumulation of inflammatory cells are the histological landmarks of abdominal aortic aneurysm (AAA). In larger aneurysms, an intraluminal thrombus is almost always present. It has been suggested that the thrombus predisposes for AAA rupture. LÄS MER