Sökning: "eflornithine"

Hittade 5 avhandlingar innehållade ordet eflornithine.

  1. 1. On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios

    Författare :Rasmus Jansson Löfmark; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Human African trypanosomiasis; HAT; Pharmacokinetics; NONMEM; Stereoselectivity; Eflornithine; Tissue distribution;

    Sammanfattning : Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is efficacious but the cumbersome intravenous administration leaves numerous patients untreated. LÄS MER

  3. 2. Drug Analysis : Bioanalytical Method Development and Validation

    Författare :Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Nyckelord :Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. LÄS MER

  4. 3. Oral eflornithine treatment of late-stage human African trypanosomiasis

    Författare :Mikael Boberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

    Sammanfattning : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. LÄS MER

  5. 4. Development of analytical methods for determination of drugs, used against tropical diseases, in biological fluids

    Författare :Mikaela Malm; Högskolan Dalarna; []
    Nyckelord :;

    Sammanfattning : The overall aim of this thesis was to develop analytical methods for determination of drugs, used against tropical diseases, in biological fluids. For the treatment of malaria, piperaquine (PQ) is used in combination with another antimalarial. LÄS MER

  7. 5. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

    Författare :Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER