Sökning: "efflux"
Visar resultat 16 - 20 av 159 avhandlingar innehållade ordet efflux.
16. Efflux of Sucrose from Mesophyll Cells during Apoplastic Phloem Loading in Pea
Sammanfattning : Efflux of sucrose from photosynthesizing mesophyll cells into the apoplastic space, during apoplastic phloem loading, was investigated using suspension of protoplasts and inside-out plasma membrane vesicles isolated from mature leaves of in Pisum sativum L. cv. Fenomen. LÄS MER
17. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity
Sammanfattning : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. LÄS MER
18. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions
Sammanfattning : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. LÄS MER
19. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury
Sammanfattning : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. LÄS MER
20. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition
Sammanfattning : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. LÄS MER