Sökning: "effector delivery"
Visar resultat 6 - 10 av 23 avhandlingar innehållade orden effector delivery.
6. Natural killer cell inhibitory and activating receptors : regulatory role in effector functions against normal and tumor cells
Sammanfattning : Natural killer (NK) cells can mediate effector functions as cytokine production and degranulation dependent cytotoxicity against cells that have become aberrant by mutagenesis or by infection. As part of the innate immunity, the NK cells are most important in the direct early defense against infections, and also in indirect shaping of the later adaptive response. LÄS MER
7. In vivo bioluminescence imaging in preclinical trials of genetic vaccines
Sammanfattning : DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of genes encoding microbial and tumor antigens or allergens in the cells of vaccine recipients. LÄS MER
8. Role of the Yersinia protein YopK in microbe-host interactions
Sammanfattning : There are three human pathogenic species of the genus Yersiniae: Yersinia pestis, Yersinia enterocolitica, and Yersinia pseudotuberculosis. To cause disease, these strains inhibit several key innate defense mechanisms, including phagocytosis, the critical process for bacterial clearance. LÄS MER
9. Type III secretion- the various functions of the translocon operon in bacterial pathogenesis
Sammanfattning : In order to establish colonisation of a human host, pathogenic Yersinia use a type III protein secretion system to directly intoxicate host immune cells. Activation of this system requires target cell contact and is a highly regulated process. LÄS MER
10. Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies
Sammanfattning : Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. LÄS MER