Sökning: "effector delivery"

Visar resultat 11 - 15 av 23 avhandlingar innehållade orden effector delivery.

1. 11. Dendritic cells in allergy In vitro models for studies of the human immune response

   Författare :Kristina Larsson; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; vaccine; Th2; transcriptional profiling; T cell; nanosphere; Immunologi; MUTZ-3; microarray; in vitro model; Allergic rhinitis; dendritic cell; serologi;

   Sammanfattning : This thesis, which is based on four original papers, deals with human dendritic cells (DCs) in immunity and allergy. DCs play a key role in the regulation of immune responses by acting as the sentinels of the immune system, specialized in the uptake of a diverse range of antigens. LÄS MER

3. 12. Infection biology of Chlamydia pneumoniae

   Författare :Leslie Bailey; Sven Bergström; Peter Nordström; Anders Waldenström; Kenneth Fields; Umeå universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Chlamydia pneumoniae; Type three secretion system; Bone; Medicine; Medicin;

   Sammanfattning : There are two main human pathogens in the family of Chlamydiaceae. Different serovars of Chlamydia trachomatis cause sexually-transmitted disease and eye infections whereas C. pneumoniae (TWAR) is a common cause of community-acquired respiratory infection. LÄS MER

4. 13. Coordinating type III secretion system biogenesis in Yersinia pseudotuberculosis

   Författare :Jyoti Mohan Gurung; Matthew S Francis; Maria Fällman; Dirk Linke; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; type III secretion system; YscX; YscY; YopN; TyeA; secretion signal; N-terminal region; site-directed mutagenesis; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

   Sammanfattning : Various Gram-negative bacteria utilize type III secretion system (T3SS) to deliver effectors into eukaryotic host cells and establish mutualistic or pathogenic interactions. An example is the Ysc-Yop T3SS of pathogenic Yersinia species. LÄS MER

5. 14. CNS-Targeted Cell Therapy for Multiple Sclerosis

   Författare :Moa Fransson; Angelica Loskog; Tomas Olsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR; Targeting; Suppressive cells; Foxp3; Tregs; Clinical immunology; Klinisk immunologi; Immunologi; Immunology;

   Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. LÄS MER

7. 15. Strengthening the pillars of cancer immunotherapy

   Författare :Maarten Alexander Ligtenberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The treatment of disease in cancer patients by harnessing the potent mechanisms that exist within the immune system is not a novel approach, and has been first attempted more than a century ago. During the major part of this century cancer immunotherapy has been relegated to the periphery of standard care for patients. LÄS MER