Sökning: "eNOS"

Visar resultat 11 - 15 av 46 avhandlingar innehållade ordet eNOS.

1. 11. NADPH oxidase and xanthine oxidoreductase as targets and regulators of the nitrate-nitrite-nitric oxide pathway

   Författare :Maria Peleli; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) and xanthine oxidoreductase (XOR) with a concomitant decrease in the bioavailability of nitric oxide (NO) from eNOS contributes to the development of cardiovascular and metabolic disorders. Extensive research has proven the existence of an alternative NOS-independent pathway for NO production. LÄS MER

3. 12. Nitric oxide synthase in female reproductive and urinary organs: Hormonal regulation and functional significance

   Författare :Jassim Al-Hijji; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gynaecology; Obstetrics; estrogen; trophoblast; placenta; vagina; Nitric oxide; uterus; ovarian steroids; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

   Sammanfattning : Nitric oxide synthase (NOS) activity was studied in cytosolic and particulate fractions in reproductive organs from rabbit (uterus and vagina) and rat (uterus, vagina and cervix). NOS was found predominantly in cytosolic fractions in all tissues and the activity of NOS in both fractions was highly Ca2+ dependent. LÄS MER

4. 13. Inducible nitric oxide synthase in experimental urinary tract infection

   Författare :Mirjana Poljakovic; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; host defense; cell viability; nitrate; lipopolysaccaride; cytokines; sphingomyelinase; mitogen activator protein kinase; nitric oxide; nitrotyrosine; E. coli; cyclooxygenase; urinary tract infection; prostaglandins; urothelium; bladder; kidney; NADPH diaphorase histochemistry; nitric oxide synthase; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; nefrologi; Urologi; nephrology; Infections; Infektioner;

   Sammanfattning : Urinary tract infection (UTI) is among the most common bacterial infections in humans and the majority are caused by Escherichia coli (E. coli). Abundant evidence indicates that nitric oxide (NO) produced by the inducible NO synthase (iNOS) plays an important role in host defense against infection. LÄS MER

5. 14. Therapeutic myocardial angiogenesis and its pharmacological modulation

   Författare :Anwar J Siddiqui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Angiogenesis; arteriogenesis; ischemic heart; vascular endothelial growth factor; angiopoietin and receptor;

   Sammanfattning : Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of combined angiogenic factors. LÄS MER

7. 15. Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular endothelium

   Författare :Niklas Bergh; Göteborgs universitet; []
   Nyckelord :ex vivo perfusion system; biomechanical; endothelium; shear stress; tensile stress; pulsatile; TNF-α; JNK; hemostatic genes;

   Sammanfattning : The vascular endothelium is a multifunctional interface constantly exposed to biomechanical forces such as shear and tensile stress. Biomechanical stress is involved in the pathophysiological process of the vessel wall and thus affects vascular remodeling, atherosclerosis and thrombogenesis. LÄS MER