Sökning: "dyslipidemia"

Visar resultat 16 - 20 av 89 avhandlingar innehållade ordet dyslipidemia.

  1. 16. Studies of atherogenic lipoproteins using mass spectrometry-based lipidomics

    Författare :Marcus Ståhlman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipids; lipoproteins; atherogenesis; lipidomics; type 2 diabetes; mass spectrometry;

    Sammanfattning : The prevalence of type 2 diabetes is increasing worldwide and is about to reach epidemic proportions. The disease is often associated with dyslipidemia which is characterized by an atherogenic lipoprotein profile including elevated serum triacylglycerol levels, low high-density lipoprotein levels and high levels of small low-density lipoproteins. LÄS MER

  3. 17. Translating Cardiac and Cardiometabolic GWAS Using Zebrafish

    Författare :Benedikt von der Heyde; Marcel den Hoed; Anastasia Emmanouilidou; Erik Ingelsson; Shawn Burgess; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Zebrafish; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Genome-wide association studies (GWAS) have identified thousands of loci associated with cardiac and cardiometabolic traits. However, the trait-associated variants usually do not clearly point to causal gene(s), mechanism(s) or tissue(s). Model systems that allow for a comprehensive and quick candidate gene screening are necessary, ideally in vivo. LÄS MER

  4. 18. The role of PPARalpha and growth hormone in hepatic lipid metaboism and atherosclerosis

    Författare :Anna Ljungberg; Göteborgs universitet; []
    Nyckelord :growth hormone; PPARalpha; atherosclerosis; lipid metabolism; fatty acids; apoB; ; ADRP; triglycerides; PGC-1; liver;

    Sammanfattning : Dyslipidemia mainly results from oversecretion of apoB-containing lipoproteins from theliver and is one of the most important risk factors for the development of atherosclerosis.Growth hormone (GH) plays a key role in the regulation of lipoprotein metabolism and thus,disturbances in GH secretion are associated with dyslipidemia and cardiovascular disease. LÄS MER

  5. 19. Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia

    Författare :Birkneh Tilahun Tadesse; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ending the HIV/AIDS epidemic by 2030 is a global agenda. To meet this global goal, having safe and effective antiretroviral therapy is a key requirement. In Ethiopia, the safety and efficacy of combination antiretroviral therapy in HIV infected pediatric population is poorly studied. LÄS MER

  7. 20. Effects of immunosuppressive drugs on human adipose tissue metabolism

    Författare :Maria J Pereira; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER