Sökning: "dynorphin A"

Visar resultat 16 - 20 av 38 avhandlingar innehållade orden dynorphin A.

1. 16. Molecular mechanisms underlying increased PDYN and dynorphin expression in the prefrontal cortex of alcoholic men

   Författare :Richard Henriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alcohol dependence is a chronic relapsing disorder caused by drug x gene x environment interactions for which pharmacotherapy is but moderately effective. The prefrontal cortex is a brain region important for cognitive control / behavioral flexibility which function is impaired in alcoholics. LÄS MER

3. 17. The hippocampal opioid system : role in spatial learning

   Författare :Johan Sandin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :opioid; dynorphin; nociceptin; hippocampus; learning; memory; acetylcholine; HPLC; microinjections;

   Sammanfattning : The main aim of the present thesis was to study the role of the endogenous hippocampal opioid system, and in particular, the role of dynorphin B and nociceptin, in spatial learning. The effects of bilateral infusion (using chronic cannulae) of dynorphin B into the dorsal hippocampus (CA3-region), an area containing a high number of dynorphin-containing neurons, were examined in the Morris swim-maze, a spatial task dependent on hippocampal functioning. LÄS MER

4. 18. Characterization of neuropeptide, monoamine, and amino acid release in the basal ganglia of the rat : neuronal dependence and reciprocal interactions

   Författare :Zhi-Bing You; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :amino acids cholecystokinin dopamine dynorphin microdialysis morphineneostriatum rat substantia nigra.;

   Sammanfattning : Functional interactions in the basal ganglia of rats were characterized with in vivomicrodialysis. The study was mainly focused on the dynorphin and cholecystokinin (CCK) systems. The extracellular levels of both dynorphin B and CCK were found in the pM range inthe neostriatum and substantia nigra under basal conditions. LÄS MER

5. 19. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons

   Författare :Martin Werme; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :VTA; nucleus accumbens; wheel running; exercise; drugs of abuse; addiction; compulsive; deltaFosB; Nurr1; Dynorphin;

   Sammanfattning : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. LÄS MER

7. 20. Behavioural and neurochemical effects and changes in gene expression in inflammatory and neuropathic pain

   Författare :Eva Schött; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Inflammatory pain; neuropathic pain; pain-related behaviour; weight bearing; preemptive analgesia; immediate early genes; substance P; dynorphin; cholecystokinin; microdialysis;

   Sammanfattning : Chronic pain is a common clinical problem, which causes great suffering, and there is a great need for better analgesic drugs and strategies to counteract the transition of acute pain into chronic pain states. In studies of neurochemical mechanisms in animal models of chronic pain it is important to study also the development of spontaneous pain-related behaviour and sensory abnormalities (i. LÄS MER