Sökning: "drug screens"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden drug screens.

  1. 1. Structural studies of drug targets and a drug metabolizing enzyme

    Författare :Daniela Cederfelt; U. Helena Danielson; Doreen Dobritzsch; Inari Kursula; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biophysics; Protein structure; X-ray crystallography; Cryogenic electron microscopy; Enzymology; Drug discovery; Pyrimidine degradation; Biokemi; Biochemistry;

    Sammanfattning : The work presented in this thesis describes how structural information about a protein can be acquired, and how it can be used to answer scientific questions about proteins’ function, their dynamic behaviour and their interactions with other proteins or ligands.The catalytic function of the pyrimidine-degrading, drug metabolizing enzyme β-ureidopropionase (βUP) is dependent on the shift between oligomeric states. LÄS MER

  3. 2. A Drosophila Disease-Model for Transthyretin-associated Amyloidosis

    Författare :Malgorzata Pokrzywa; Erik Lundgren; Damian Crowther; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transthyretin; amyloid; amyloidosis; Drosophila; transthyretin-associated amyloidosis; Familial amyloid polyneuropathy; neurodegeneration; serum amyloid P component; Non-steroidal Anti-Inflammatory Drugs; drug screens; Molecular biology; Molekylärbiologi;

    Sammanfattning : Amyloidoses comprise a group of gain-of-toxic function protein misfolding diseases, in which normally soluble proteins in their functional state undergo conformational changes into highly organized and generally intractable thread-like aggregates, termed amyloid fibrils. These structures accumulate predominantly in the extracellular space but growing evidence suggests that amyloids may start to form intracellularly. LÄS MER

  4. 3. Computational and chemical approaches to drug repurposing

    Författare :Xuexin Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two primary approaches: computational and chemical. LÄS MER

  5. 4. General practitioners' decision-making on drug treatment of hypercholesterolaemia

    Författare :Lars Backlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :General practice; guidelines; decision-making; judgements; Clinical Judgement Analysis; case vignettes; hypercholesterolaemia; think-aloud; process tracing;

    Sammanfattning : Drug treatment of elevated cholesterol values may be indicated for individuals at high risk for cardiovascular disease and as a complement to lifestyle advice. Guidelines recommend a numerical risk calculation as the basis for selecting the individuals at highest risk among those who are free from previous cardiovascular disease (primary prevention). LÄS MER

  7. 5. CRISPR-based drug target discovery : implications for CRISPR-based therapies

    Författare :Long Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The CRISPR system was discovered in prokaryotic cells, and it is now one of the most efficient molecular tools to modify genes in eukaryotic cells. It is widely used to inactivate or modify genes in cell lines, animal models, and is also used in several clinical gene therapy trials. LÄS MER