Sökning: "drug efflux"

Visar resultat 21 - 25 av 72 avhandlingar innehållade orden drug efflux.

  1. 21. Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance

    Författare :Maria Isabel Mendes Veiga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development and spread of drug resistance among malaria parasites. LÄS MER

  3. 22. Drug resistance in acute myeloid leukemia : clinical and experimental studies

    Författare :Bertil Uggla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The long-term result of chemotherapy in acute myeloid leukemia (AML) is poor, even though a majority of AML patients initially respond to chemotherapy and achieve complete remission (CR). Initially resistant disease as well as relapse is a result of resistance to chemotherapy drug resistance. LÄS MER

  4. 23. Chloride transport and inflammation in cystic fibrosis airways

    Författare :Georgia Varelogianni; Godfried Roomans; Marie Johannesson; Ólafur Baldersson; Örebro universitet; []
    Nyckelord :Cystic fibrosis; CFTR; chloride efflux; N-acetylcysteine; ambroxol; duramycin; Nod-like receptors; cytokines; Medicin; Medicine;

    Sammanfattning : Cystic fibrosis (CF) is one of the most common lethal, autosomal recessive inherited diseases among Caucasians. It is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel activated by cyclic AMP. LÄS MER

  5. 24. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Författare :Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Sammanfattning :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER

  7. 25. Modelling Approaches to Molecular Systems Biology

    Författare :David Fange; Måns Ehrenberg; Johan Elf; Terence Hwa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stochastic reaction-diffuion kinetics; antibiotic drugs; efflux pumps; amino acid biosynthesis; Min-system; rRNA operon; transcription; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Implementation and analysis of mathematical models can serve as a powerful tool in understanding how intracellular processes in bacteria affect the bacterial phenotype. In this thesis I have implemented and analysed models of a number of different parts of the bacterium E. coli in order to understand these types of connections. LÄS MER