Sökning: "drug dependence"

Visar resultat 1 - 5 av 106 avhandlingar innehållade orden drug dependence.

  1. 1. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

    Författare :Sibylle Neuhoff; Per Artursson; Anna-Lena Ungell; Patrick Augustijns; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

    Sammanfattning : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. LÄS MER

  3. 2. Sedative or hypnotic drug dependence : personality and neuropsychological characteristics

    Författare :Lena Holm; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Personlighetspsykologi; Droger; Test. Rorschach; Neuropsykologi;

    Sammanfattning : .... LÄS MER

  4. 3. Psychoactive prescription drug use disorders, misuse and abuse : Pharmacoepidemiological aspects

    Författare :Micaela Tjäderborn; Staffan Hägg; Johan Ahlner; Anna Jönsson; Morten Andersen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychoactive prescription drugs; psychotropic drugs; prescription drug use disorders; prescription drug misuse; abuse; pharmacovigilance; drug utilization; pharmacoepidemiology;

    Sammanfattning : Background: There is a widespread and increasing use of psychoactive prescription drugs, such as opioid analgesics, anxiolytics, hypnotics and anti-epileptics, but their use is associated with a risk of drug use disorder, misuse and abuse. Today, these are globally recognized and emerging public health concerns. LÄS MER

  5. 4. Benzodiazepine and opioid dependence. Clinical and meta-analytical studies

    Författare :Björn Axel Johansson; Kliniskt Centrum för Hälsofrämjande Vård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clinical psychology; psychosomatics; Psychiatry; meta-analysis; opioid dependence; RCT; naltrexone; prescribed drugs; maintenance treatment; methadone; withdrawal symptoms; benzodiazepine dependence; DSM-IV; Psykiatri; klinisk psykologi; psykosomatik;

    Sammanfattning : The thesis contains 4 papers, two clinical studies and two meta-analyses. In the BZD taper study (Paper I) 21 BZD dependent (DSM-IV) patients were included for a 10-day inpatient detoxification. The average defined daily dose (DDD) was 4.7 doses. LÄS MER

  7. 5. Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model

    Författare :Pia Steensland; Christina Gianoulakis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Anabolic Androgenic Steroids AAS ; aggression; alcohol intake; defensive behaviours; dependence; opioid peptides; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Sammanfattning : A new group of anabolic androgenic steroid (AAS) users has developed during the last two decades. This group consists primarily of young men interested in improving their physical appearance. Within this group, AAS are sometimes used together with other illicit drugs, alcohol and nicotine. LÄS MER