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Visar resultat 1 - 5 av 626 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Management control and strategy : a case study of pharmaceutical drug development

   Författare :Fredrika Berglund; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Management control systems; Tight control; Loose control; Interactive control; Diagnostic control; Budget; Portfolio management; Project management; Goals and Objectives systems; Business strategy; Research Development; Pharmaceutical; Computer science; Datavetenskap; Economic Information Systems; Ekonomiska informationssystem;

   Sammanfattning : How are formal management controls designed and used in research & development (R&D)? The purpose of this study is to explain how such systems are designed and used in formulating and implementing strategies in a pharmaceutical product development organisation. The study uses a contingency approach to investigate how the control system is adjusted to the business strategy of the firm. LÄS MER

3. 2. Nonlinear Modeling and Feedback Control of Drug Delivery in Anesthesia

   Författare :Margarida M. Silva; Alexander Medvedev; Teresa Mendonça; Torbjörn Wigren; Robain De Keyser; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; anesthesia; drug delivery; feedback control; nonlinear modeling; pharmacokinetics pharmacodynamics; PID control; system identification; Wiener model; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

   Sammanfattning : General anesthesia is a drug-induced reversible state where neuromuscular blockade (NMB), hypnosis, and analgesia (jointly denoted by depth of anesthesia - DoA) are guaranteed. This thesis concerns mathematical modeling and feedback control of the effect of the muscle relaxants atracurium and rocuronium, the hypnotic propofol, and the analgesic remifentanil. LÄS MER

4. 3. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

   Författare :Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

   Sammanfattning : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. LÄS MER

5. 4. Polisen och narkotikaproblemet : från nationella aktioner mot narkotikaprofitörer till lokala insatser för att störa missbruket

   Författare :Anders Kassman; Hans Klette; Stockholms universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; abuse; addiction; control; drugs; media; moral panic; narcotics; the penal law on narcotics; organization; police; policy; prosecutor general; repression; Sweden; street dealer; time-series; TV; telephone-tapping; Sociology; sociologi; SOCIAL SCIENCES;

   Sammanfattning : The subject of this study is the policing of the drug problem during the period between the nationalization of the police force in 1965 and the introduction of imprisonment as a penalty for drug consumption in 1993. The influence of four key factors are discussed: legislation, organization, the conception of and the attention paid to the drug problem. LÄS MER

7. 5. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

   Författare :Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. LÄS MER