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Visar resultat 1 - 5 av 53 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Methods for longitudinal brain imaging studies with dropout

    Författare :Tetiana Gorbach; Xavier de Luna; Anders Lundquist; Martin A. Lindquist; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Missing data; nonignorable dropout; sensitivity analysis; uncertainty intervals; pattern-mixture models; aging; cognition; MRI; brain structure; resting-state functional connectivity; Statistics; statistik;

    Sammanfattning : One of the challenges in aging research is to understand the brain mechanisms that underlie cognitive development in older adults. Such aging processes are investigated in longitudinal studies, where the within-individual changes over time are observed. However, several methodological issues exist in longitudinal analyses. LÄS MER

  3. 2. Pharmacometric Models in Anesthesia and Analgesia

    Författare :Marcus Björnsson; Ulrika Simonsson; Mats Karlsson; Leonid Gibiansky; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Anesthesia; Analgesia; Dropout; NONMEM; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Modeling is a valuable tool in drug development, to support decision making, improving study design, and aid in regulatory approval and labeling. This thesis describes the development of pharmacometric models for drugs used in anesthesia and analgesia. LÄS MER

  4. 3. Therapeutic Alliance in General Psychiatric Care

    Författare :Håkan Johansson; Institutionen för psykologi; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; clinical psychology; psychosomatics; Psychiatry; patient factors; ward atmosphere; patient satisfaction; psychiatric care; helping alliance; working alliance; psychotherapy; psychiatry; therapeutic alliance; therapeutic relationship; dropout; psykosomatik; klinisk psykologi; Psykiatri;

    Sammanfattning : The main aim of the thesis was to study different aspects of the therapeutic relationship in general psychiatric care, within various routine psychiatric settings with a variety of diagnostic patient groups and different staff groups. The first study investigated the patients' opinion on what constituted good psychiatric care. LÄS MER

  5. 4. Measuring eating disorder outcome : definitions, dropout and patients' perspectives

    Författare :Tabita Björk; Claes Norring; David Clinton; Gerd Ahlström; Bruno Hägglöf; Örebro universitet; []
    Nyckelord :MEDICINE; MEDICIN; Medicine; Medicin;

    Sammanfattning : Background: Despite a plethora of research, there are serious limitations in our knowledge of outcome in eating disorders. Almost all studies have been compromised by the problem of treatment dropout or non-participation in follow-ups. LÄS MER

  7. 5. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression

    Författare :Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Sammanfattning : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. LÄS MER