Sökning: "downstream evolution"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden downstream evolution.

  1. 1. Bioinformatics, evolution and revolution in our understanding of toxin-antitoxin systems

    Författare :Chayan Kumar Saha; Gemma C. Atkinson; Victoria Shingler; Gipsi Lima Mendez; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Alarmones; Evolution; Gene neighbourhood; Toxin; Antitoxin; molekylärbiologi; Molecular Biology;

    Sammanfattning : Bacteria experience a wide range of natural challenges during their life cycles, to which they must respond and adapt to live. Under stressed conditions such as amino acid starvation, bacteria slow down their growth mechanism by producing small alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp. LÄS MER

  3. 2. Birds as a Model for Comparative Genomic Studies

    Författare :Axel Künstner; Hans Ellegren; Hanna Johannesson; Chris Ponting; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Birds; Selection; Gene expression; Sequence evolution; Next-generation sequencing; Comparative genomics; Molecular evolution; Genomics; Substitution Rates; Non-coding DNA; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : Comparative genomics provides a tool to investigate large biological datasets, i.e. genomic datasets. In my thesis I focused on inferring patterns of selection in coding and non-coding regions of avian genomes. LÄS MER

  4. 3. Staphylococcal surface display in directed evolution

    Författare :Nina Kronqvist; Stefan Ståhl; Mats A. A. Persson; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; combinatorial library; directed evoluation; Gram-positive bacteria. protein engineering; Bioengineering; Bioteknik;

    Sammanfattning : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. LÄS MER

  5. 4. The diapause switch : Evolution of alternative developmental pathways in a butterfly

    Författare :Inger Marie Aalberg Haugen; Karl Gotthard; Dan Hahn; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental plasticity; phenotypic plasticity; developmental switch; threshold trait; life-cycle regulation; direct development; Lepidoptera; zoologisk ekologi; Animal Ecology;

    Sammanfattning : Diapause decision is a classic example of a threshold switch mechanism with cascading effects on morphology, behaviour and life-history traits. This thesis addresses the downstream effects of the insect diapause switch, with the main focus on pathway-specific regulation of life-history traits, using the speckled wood butterfly (Pararge aegeria) as a study species. LÄS MER

  7. 5. Evolutionary Approaches to Sequence Alignment

    Författare :Marcin Bogusz; Simon Whelan; Jeffrey Thorne; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular evolution; multiple sequence alignment; pair hidden Markov models; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Molecular evolutionary biology allows us to look into the past by analyzing sequences of amino acids or nucleotides. These analyses can be very complex, often involving advanced statistical models of sequence evolution to construct phylogenetic trees, study the patterns of natural selection and perform a number of other evolutionary studies. LÄS MER