Sökning: "downstream effects"

Visar resultat 1 - 5 av 355 avhandlingar innehållade orden downstream effects.

  1. 1. Effects of Watershed Dynamics on Water Reservoir Operation Planning : Considering the Dynamic Effects of Streamflow in Hydropower Operation

    Författare :Nicholas Zmijewski; Anders Wörman; Andrea Bottacin-Busolin; Francesca Pianosi; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; reservoir operation; dispersion processes; wave diffusion; multi-objective operation; water resource management; discharge variability; power spectrum analysis; Byggvetenskap; Civil and Architectural Engineering;

    Sammanfattning : Water reservoirs are used to regulate river discharge for a variety of reasons, such as flood mitigation, water availability for irrigation, municipal consumption and power production purposes. Recent efforts to increase the amount of renewable power production have seen an increase in intermittent climate-variable power production due to wind and solar power production. LÄS MER

  3. 2. Downstream effects of master regulators in two brain diseases

    Författare :Sebastian Braun; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rett syndrome; brain tumor development; gene regulation; neural stem cells; cell of origin; BMI1;

    Sammanfattning : In paper one, we investigated how the pharmacological activation and inhibition of the glucocorticoid system affects lifespan and symptoms in a mouse model for RTT. We performed a long-term drug treatment study with the GR activator corticosterone and the GR inhibitor RU486 under which we measured the lifespan and onset of RTT-like symptoms of male Mecp2-null and female Mecp2 heterozygous mice in comparison to untreated mutant and to treated and untreated wild-type animals. LÄS MER

  4. 3. Canertinib-induced leukemia cell death signaling : effects of a pan-ERBB inhibitor

    Författare :Cecilia Trinks; Thomas Walz; Jan-Ingvar Jönsson; Anna-Lotta Hallbeck; Dan Grandér; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Acute myelogenous leukemia (AML) is the most common acute leukemia affecting adults, the second most frequent leukemia in children, and remains one of the most difficult to cure. Despite a substantial progress in understanding the pathogenesis of AML, general and rather unspecific cytostatic drugs such as cytarabine and anthracyclins still make up the cornerstones of therapy. LÄS MER

  5. 4. Myc-induced Lymphomagenesis : In vivo assessment of downstream pathways

    Författare :Sara Rimpi; Jonas Nilsson; Juha Klefström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; lymphomagenesis; Aurora kinases; polyamine; glycolysis; targeting; mouse models of cancer; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Myc oncogenes encode transcription factors that bind to E-box sequences in DNA, driving the expression of a large number of target genes and are deregulated in approximately 70% of human cancers. Deregulated Myc expression cause enhanced proliferation (which is counteracted by apoptosis), angiogenesis and cancer. LÄS MER

  7. 5. Allies Yet Rivals : Input Joint Ventures and Their Competitive Effects

    Författare :Mikael Nordberg; Lars Hultkrantz; Mats Bergman; Tommaso Valletti; Uppsala universitet; []
    Nyckelord :Economics; joint venture; input; infrastructure; quality; oligopoly; Nationalekonomi; nationalekonomi; Economics;

    Sammanfattning : Essay I explores the competitive effects of input joint ventures, more precisely the connection between horizontal product differentiation and competition. Four quantity-setting downstream firms jointly and symmetrically own two upstream firms in pairs. LÄS MER