Sökning: "dose-response curves"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden dose-response curves.

  1. 1. Novel methods for dose-response meta-analysis

    Författare :Alessio Crippa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dose–response meta-analysis is a statistical procedure for combining and contrasting the evidence on the association between a continuous exposure and the risk of a health outcome. Different papers refined selected aspects of the methodology, such as implementation of flexible strategies and extensions to multivariate meta-analysis. LÄS MER

  3. 2. Topics in multifractal measures, nonparametrics and biostatistics

    Författare :Attila Frigyesi; Anestesiologi och intensivvård; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; confidence interval; mixed effects; Statistics; operations research; programming; actuarial mathematics; Statistik; operationsanalys; programmering; aktuariematematik; operational model of pharmacological agonism; concentration-response curves; dose-response curves; ventilation perfusion scintigraphy; V Q-scan; pulmonary embolism; automated method; box counting; correlation dimension; Hentschel-Procaccia dimension; Rényi dimension; generalized dimensions; fractal dimension estimation; dimension spectrum; multifractal measures; kernel density estimates; absolute continuity; singular distribution functions;

    Sammanfattning : This thesis consists of four papers. The first two papers, which comprise the main part of the thesis, deal with an unexpected connection between kernel density estimators and dimension spectra for multifractal measures. LÄS MER

  4. 3. Studies of ligand- and temperature-gated ion channels using microfluidic methods

    Författare :Maria Millingen; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; solution exchange; desensitization; temperature-gated; ion channel; temperature control; ligand-gated; TRPV1; GABAA receptor; microfluidics;

    Sammanfattning : This thesis describes the studies of the GABAA receptor, a ligand-gated ion channel, and the ligand- and temperature-gated ion channel TRPV1. The desensitization behavior of both of these proteins has been studied for different conditions, using a microfluidic device for superfusion. LÄS MER

  5. 4. Patch-clamp studies of the GABAA receptor using microfluidic methods

    Författare :Maria Millingen; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channel; microfluidics; GABAA receptor;

    Sammanfattning : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. LÄS MER

  7. 5. Radiotherapy Gel Dosimetry: Development and Application of Normoxic Polymer Gels

    Författare :Helen Gustafsson; Malmö Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical physics; radiology; tomography; medical instrumentation; Klinisk fysiologi; tomografi; medicinsk instrumentering; Radiofarmaceutisk teknik; Radiopharmaceutical technology; proton; LET; FT Raman spectroscopy; MRI; normoxic gel; IMRT; 3D verification; polymer gel dosimetry; radiologi;

    Sammanfattning : In many radiotherapy applications, true three-dimensional dosimetry with good spatial resolution that can be achieved in a single measurement would be of great value. Polymer gel dosimetry fulfils many of the demands on such a system. In this study, methods to facilitate the implementation of gel dosimetry have been investigated. LÄS MER