Sökning: "dose response"
Visar resultat 6 - 10 av 880 avhandlingar innehållade orden dose response.
6. In vivo dose, dose-response and cancer risk assessment
Sammanfattning : .... LÄS MER
7. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures
Sammanfattning : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. LÄS MER
8. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling
Sammanfattning : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. LÄS MER
9. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data
Sammanfattning : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. LÄS MER
10. Estimation and optimal designs for multi-response Emax models
Sammanfattning : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. LÄS MER