Sökning: "dose adaptation"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden dose adaptation.

1. 1. Dose Adaptation Based on Pharmacometric Models

   Författare :Johan Wallin; Mats Karlsson; Lena Friberg; Maria Garrido; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Many drugs exhibit major variability in both pharmacokinetic (PK) and pharmacodynamic (PD) parameters that prevents the use of the same dose for all patients. Variability can occur both between patients (IIV) as well as within patients over the course of time (IOV). LÄS MER

3. 2. Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A

   Författare :João A. Abrantes; Mats Karlsson; Elisabet I. Nielsen; Siv Jönsson; Ron Mathôt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bayesian forecasting; coagulation factor VIII; dose adaptation; hemophilia haemophilia A; inter-occasion variability; NONMEM; pharmacodynamics; pharmacokinetics; pharmacometrics; therapeutic drug monitoring; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches. LÄS MER

4. 3. Cone Beam Computed Tomography - radiation dose and image quality assessments

   Författare :Sara Lofthag-Hansen; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cone beam computed tomography; anatomic landmarks; dose-area product; image quality; implant planning; periapical diagnosis; radiation dosimetry;

   Sammanfattning : Diagnostic radiology has undergone profound changes in the last 30 years. New technologies are available to the dental field, cone beam computed tomography (CBCT) as one of the most important. LÄS MER

5. 4. Effects of some ward routines on behavioural and physiological adaptation to breast-feeding

   Författare :Eva Nissen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast-feeding; oxytocin; prolactin; cortisol; Caesarean section; newborn infantbehaviour; pethidine.Stockholm; December 1996;

   Sammanfattning : The overall aim of this thesis was to study how early breast-feeding would be influenced by pethidine given during labour and by an emergency Caesarean section. Eighteen mother-infant pairs which were exposed and 26 which were not exposed to pethidine during labour were observed the first two hours after birth. LÄS MER

7. 5. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

   Författare :Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

   Sammanfattning : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. LÄS MER