Sökning: "dorsal root ganglion"

Visar resultat 6 - 10 av 52 avhandlingar innehållade orden dorsal root ganglion.

  1. 6. Studies on Peripheral Nerve Regeneration: Microdispensing, Neurite Guidance and Galectins

    Författare :Per Gustavsson; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; Schwann cells; sciatic nerve; dorsal root ganglia; DRG; neurite guidance; galectins; inkjet; microdispensing; peripheral nervous system; nerve regeneration; Animal physiology; Djurfysiologi; Biotechnology; Bioteknik;

    Sammanfattning : The present thesis describes development of a microdispenser-based technique to create of protein patterns for neurite guidance. The same technique was also developed to allow direct positioning of dissociated cells, including neurons, on cell culture substrates. Finally the role of galectin-3 and 8 during nerve regeneration was investigated. LÄS MER

  3. 7. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

    Författare :Peter Wiklund; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NT-4; NT-3; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. LÄS MER

  4. 8. Bioelectronic Devices for Targeted Drug Delivery and Monitoring of Microbial Electrogenesis

    Författare :Arghyamalya Roy; Daniel T Simon; Klas Tybrandt; Christopher Proctor; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electrophoresis; Extracellular Electron Transfer EET ; Ion Exchange Membranes IEM ; Drug Delivery; Bupivacaine; Chronic Neuropathic Pain; Microfabrication; Inkjet Printing; Organic Electrochemical Transistor OECT ; Fumarate; Shewanella oneidensis; Dorsal Root Ganglia DRG ; Organic Electronic Ion Pump OEIP ;

    Sammanfattning : Despite a range of pain therapies available in the market, 70% of patients report so-called “breakthrough pain”. Coupled with global issues like opioid crisis, there is a clear need for advanced therapies and technologies for pain management. LÄS MER

  5. 9. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

    Författare :Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

    Sammanfattning : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. LÄS MER

  7. 10. Neuroprotection and axonal regeneration after peripheral nerve injury

    Författare :Dag Welin; Lev N. Novikov; Lars B. Dahlin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dorsal root ganglion; Motoneuron; Axonal reaction; Peripheral nerve injury; Nerve regeneration; N-acetylcysteine; Hand surgery; Handkirurgi; Anatomy; Anatomi; anatomi; Human Anatomy; handkirurgi; hand surgery;

    Sammanfattning : Following microsurgical reconstruction of injured peripheral nerves, severed axons are able to undergo spontaneous regeneration. However, the functional result is always unsatisfactory with poor sensory recovery and reduced motor function. LÄS MER