Avancerad sökning

Visar resultat 1 - 5 av 52 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Effects of nucleus pulposus on nerve root circulation and function. Morphologic and functional studies in an experimental model using porcine spinal nerve roots

    Författare :Gunnar Byröd; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nerve root; dorsal root ganglion; intervertebral disc; nucleus pulposus; epidural space; nerve fibre; permeability; blood flow; sciatica;

    Sammanfattning : Sciatica due to lumbar disc herniation has for many decades been viewed as a consequence of mechanical compression exerted on spinal nerve roots by the bulging disc tissues. Recent research has, however, indicated that extruded nucleus pulposus (NP) from the intervertebral disc might cause functional and endoneurial morphological changes in spinal nerve roots, without mechanical compression. LÄS MER

  3. 2. Signaling Mechanisms in the Neuronal Networks of Pain and Itch

    Författare :Katarzyna Rogoz; Klas Kullander; Malin Lagerström; Stephen McMahon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse genetics; neuronal network; glutamate; sensory neuron; dorsal root ganglion; pain; itch; Neuroscience; Neurovetenskap; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. LÄS MER

  4. 3. Sensory neuronal protection & improving regeneration after peripheral nerve injury

    Författare :Andrew McKay Hart; Mikael Wiberg; Angus McGrouther; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; cell death; TUNEL; optical disection; dorsal root ganglion; peripheral nerve; nerve conduit; Schwann cell; glial growth factor; leukaemia inhibitory factor; acetyl-L-carnitine; N-acetyl-cysteine; Neurovetenskap; Neurology; Neurologi; neurokirurgi; Neurosurgery;

    Sammanfattning : Peripheral nerve trauma is a common cause of considerable functional morbidity, and healthcare expenditure. Particularly in the ~15% of injuries unsuitable for primary repair, standard clinical management results in inadequate sensory restitution in the majority of cases, despite the rigorous application of complex microsurgical techniques. LÄS MER

  5. 4. Gene expression in the dorsal root ganglion and the role of PAI-1 and amphiregulin during regeneration

    Författare :Anna Nilsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Djurfysiologi; Animal physiology; DRG; micro-array; peripheral nerve regeneration; mouse;

    Sammanfattning : This thesis is concerned with two aspects of peripheral nerve injury. First the early changes in the gene expression of the dorsal root ganglion (DRG) in response to sciatic nerve injury as revealed by micro-array analysis. Second an examination of the effect of PAI-1 and amphiregulin on survival and axonal outgrowth from DRG. LÄS MER

  7. 5. Histochemical, biochemical and electrophysiological studies on dorsal root ganglion cultures : focusing on galanin, neuropeptide Y and glutamate

    Författare :Nora Kerekes; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute and long-term DRG cultures; aFGF; BDNF; bFGF; bradykinin; excitability; galanin; glutamate; leukemia inhibitory factor; neuropeptide Y; : NGF; regeneration; whole cell patch clamp.;

    Sammanfattning : Galanin (Gal) and neuropeptide Y (NPY) are two peptides, which are strongly up- regulated in a population of dorsal root ganglion (DRG) neurons after peripheral nerve injury (axotomy). Both peptides may be involved in the control of pain sensation, especially after nerve injury (neuropathic pain). LÄS MER