Sökning: "dopaminergic differentiation"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden dopaminergic differentiation.

  1. 1. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

    Författare :Tandis Vazin; Joakim Lundeberg; Ernest Arenas; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; dopaminergic; embryonic stem cells; differentiation; stromal cells; PA6 cells; dopamine; neurons; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi;

    Sammanfattning : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. LÄS MER

  3. 2. Stem Cell Plasticity Controlling Neuronal Differentiation Prior to Cell Transplantation

    Författare :Laurent Roybon; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Stem cells; Immunology; serology; Immunologi; serologi; transplantation;

    Sammanfattning : Parkinson's disease (PD) is the second most common neurodegenerative disease and affects 2% of the population over 65 years of age. The disease is characterized by the progressive loss of dopaminergic neurons. Over time, symptoms increase and, in particular, lead to a dramatic slowness of movements. LÄS MER

  4. 3. Derivation, propagation and differentiation of human stem and progenitor cells

    Författare :Mathilda Zetterström Axell; Göteborgs universitet; []
    Nyckelord :Human embryonic stem cells; neural progenitor cells; stem cells; differentiation; propagation; migration; cell culturing; rostral migratory stream; electrospun scaffolds;

    Sammanfattning : Neuronal loss is a common feature of many neurological disorders, including stroke, Parkinson’s disease, Alzheimer’s disease and traumatic brain injury. Human embryonic stem cells (hESCs) and hESC-derived neural progenitors (NPs) may provide a number of new ways for studying and treating diseases and injuries in the brain. LÄS MER

  5. 4. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

    Författare :Nicolaj Christophersen; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; neurotrophic factors; Parkinson s disease; microarray; dopaminergic; Embryonic stem cells; neural stem cells;

    Sammanfattning : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. LÄS MER

  7. 5. A long and winding road: Differentiating human embryonic stem cells into dopaminergic neurons

    Författare :Oktar Guloglu; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocyte; PA6; DZNEP; dopaminergic differentiation; embryonic stem cells;

    Sammanfattning : Parkinson’s disease is a progressive neurodegenerative disorder. Since the motor manifestations of the disease is associated with the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta, cell replacement therapy is a promising approach for treatment. LÄS MER