Sökning: "dopamine receptor occupancy"
Visar resultat 6 - 10 av 16 avhandlingar innehållade orden dopamine receptor occupancy.
6. A PET study on dopamine and serotonin receptor binding in the primate brain : challenges with antipsychotic drugs and amphetamine
Sammanfattning : The brain imaging technique positron emission tomography (PET) has been applied to study dopamine and serotonin neurotransmission. In schizophrenia research, an important observation is that patients with schizophrenia, when compared with controls, have higher amphetamine induced dopamine release in the striatum. LÄS MER
7. Pet imaging of two monoaminergic neurotransmitter systems in brain : studies of the norepinephrine transporter and dopamine D[2] receptor
Sammanfattning : Positron emission tomography (PET) has been widely used to study non-invasively function of the brain, pathophysiology of disease and aid in the development of new drugs. PET and selective radiolabeled molecules allow imaging of certain critical components of neurotransmission, such as pre-synaptic transporters and post-synaptic receptors in living brain. LÄS MER
8. Methological advances in the examination of the dopamine system in brain
Sammanfattning : The dopamine (DA) system in brain has attracted considerable attention in neuroscience due to its involvement in fundamental brain functions and its postulated role in the pathophysiology of several neuropsychiatric disorders. Radioligand binding techniques in vitro and in vivo, such as receptor binding autoradiography and positron emission tomography (PET) have substantially contributed to our understanding of the DA system. LÄS MER
9. Assessment of dopamine and serotonin release in the non-human primate brain using PET
Sammanfattning : The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the relationship of monoaminergic neurotransmitter systems to brain functioning and psychiatric disorders. LÄS MER
10. Mechanism of action of antipsychotic drugs : focus on the nucleus accumbens and the prefronta cortex : an experimental study
Sammanfattning : Antipsychotic drugs have been classified as typical or atypical. To achieve an effective antipsychotic effect with typical antipsychotic drugs, e.g. haloperidol, a dopamine D2 receptor blockade of about 70% seems necessary. LÄS MER