Sökning: "dopamine receptor occupancy"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden dopamine receptor occupancy.
Sammanfattning : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. LÄS MER
2. Depot neuroleptic maintenance treatment: clinical, pharmacological and neuropsychological aspects
Sammanfattning : Neuroleptic maintenance treatment is effective to reduce the risk of further episodes of schizophrenia and other chronic psychoses, except affective. Lack of insight often lead to poor compliance to the prescripted medication. Then, neuroleptics might be given as depot injections. LÄS MER
Sammanfattning : The goals of the present thesis were to study high affinity agonist binding at the D2 dopamine receptor and to explore the role of agonist induced internalization of the receptor in positron emission tomography (PET) imaging studies. For this purpose, we combined in vitro studies of radioligand binding and receptor internalization with in vivo studies in rodents using PET. LÄS MER
Sammanfattning : The dopamine D2 receptor subtype attracts considerable attention in research on the patophysiology and drug treatment of several neuropsychiatric disorders, such as schizophrenia and Parkinson s disease. The brain imaging technology Positron Emission Tomography (PET) has since long allowed for reliable quantification of the high density of dopamine D2 receptors in large brain structures such as the neostriatum. LÄS MER
5. A PET study on dopamine and serotonin receptor binding in the primate brain : challenges with antipsychotic drugs and amphetamine
Sammanfattning : The brain imaging technique positron emission tomography (PET) has been applied to study dopamine and serotonin neurotransmission. In schizophrenia research, an important observation is that patients with schizophrenia, when compared with controls, have higher amphetamine induced dopamine release in the striatum. LÄS MER