Sökning: "disulfides"
Visar resultat 1 - 5 av 34 avhandlingar innehållade ordet disulfides.
1. Metabolic reduction of mixed disulfides
Sammanfattning : .... LÄS MER
2. Methodological studies in solid phase synthesis : Linkers and applications of multi-component condensations
Sammanfattning : Solid phase synthesis has become an increasingly important tool in the synthesis of oligopolymers and small organic molecules. This thesis covers three important areas in the solid phase synthesis technique: linker strategies, reduction methods and novel routes to complex heterocycles. LÄS MER
3. Thiols and disulfides self-assembled on gold, studied by x-ray photoelectron spectoscopy
Sammanfattning : A number of different thiols and disulfides self-assembled on polycrystalline gold surfaceshave been studied using mainly AlKα-excited X-ray Photoelectron Spectroscopy (XPS), but also Fourier Transform Infrared Spectroscopy (FTIR), Ellipsometry, Contact Angles (CA), Voltammetry and Temperature Programmed Desorption (TPD).Evidence is presented in this thesis that the presence of disulfides in long chain thiolatefilms reported earlier is due to radiation damage from the X-rays used in the X-rayspectroscopies. LÄS MER
4. Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
Sammanfattning : This thesis deals mainly with the synthesis of various sulfur/selenium-containing heterocyclic compounds, many of which include structural features present in several biologically active molecules, with particular emphasis on compounds of synthetic importance, such as indoles, as well as other heteroaromatic species. In the first part, an efficient procedure toward synthesis of new 3-(arylthio)indoles based on reactions of aryl Grignard reagents or lithiated heteroaromatics with protected 3,3′-dithiobisindoles is described. LÄS MER
5. Engineering of the Ultra-stable Cystine Knot Framework of Microproteins : Design, Chemical Synthesis and Structural Studies
Sammanfattning : Ultra-stable cystine knotted microproteins, in which two disulfides and their connecting backbones form a circle that is penetrated by the third disulfide bonds, have attracted high interest due to their resistance to degradation in vitro and potential for the development of peptide drugs. This thesis gives new insights into engineering of that framework of microproteins, including approaches to their chemical synthesis, backbone engineering, structural and biological evaluations. LÄS MER
