Sökning: "dissociation constants"

Visar resultat 21 - 25 av 46 avhandlingar innehållade orden dissociation constants.

  1. 21. Identification and Characterisation of Hydroxylated PCB and PBDE Metabolites in Blood : Congener specific synthesis and analysis

    Författare :Tina Malmberg; Åke Bergman; Olov Sterner; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi;

    Sammanfattning : Hydroxylated polychlorinated biphenyls (OH-PCBs) are known metabolites of polychlorinated biphenyls (PCBs) in many mammalian, bird and fish species. Among those, certain OH-PCB congeners are strongly localised in the blood compartment of humans and wild animals. LÄS MER

  3. 22. Conformational Entropy and Protein Flexibility in Drug Design Studied by NMR Spectroscopy

    Författare :Carl Diehl; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MMP-12; Galectin-3; confomational entropy; order parameters; ITC; Protein dynamics; isothermal titration calorimetry; macrophage elastase; nuclear magnetic resonance; NMR;

    Sammanfattning : Proteins are complex molecules, present in all of the vital functions of life. The function of a protein is regulated by interactions between protein and other molecules. Drug design in pharmaceutical science aims to regulate the function of a protein by the design of synthesized molecules that binds to a protein with high affinity. LÄS MER

  4. 23. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors

    Författare :Malin Elinder; U. Helena Danielson; Maurizio Botta; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; fragment; screening; reverse transcriptase; microbicides; interaction analysis; NNRTIs; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. LÄS MER

  5. 24. Profilactin and the regulation of actin assembly and disassembly

    Författare :Håkan Larsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Actin filament assembly and disassembly are believed to be fundamental steps in the mechanism of cell motility in non-muscle cells. Profilactin is a complex between monomeric actin and a small protein, profilin, which inhibits the polymerization of the actin. LÄS MER

  7. 25. Analysis of the interaction between HIV-1 protease and inhibitors : Applications for drug discovery

    Författare :Per-Olof Markgren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : The aims of this study were to identify and characterize inhibitors of HIV-l protease aspotential leads in a drug discovery process, and to develop improved methods for suchcharacterization. More than 300 inhibitors, including linear and cyclic peptidomimetictransition state analogs and Cu2+, were analyzed. LÄS MER